caa a22 4500 445294817 CHVBK 20180317142538.0 cr unu---uuuuu 170323e20100301xx s 000 0 eng 10.1007/s11571-009-9092-2 doi (NATIONALLICENCE)springer-10.1007/s11571-009-9092-2 Effects of the anesthetic agent propofol on neural populations [Elektronische Daten] [Axel Hutt, Andre Longtin] The neuronal mechanisms of general anesthesia are still poorly understood. Besides several characteristic features of anesthesia observed in experiments, a prominent effect is the bi-phasic change of power in the observed electroencephalogram (EEG), i.e. the initial increase and subsequent decrease of the EEG-power in several frequency bands while increasing the concentration of the anaesthetic agent. The present work aims to derive analytical conditions for this bi-phasic spectral behavior by the study of a neural population model. This model describes mathematically the effective membrane potential and involves excitatory and inhibitory synapses, excitatory and inhibitory cells, nonlocal spatial interactions and a finite axonal conduction speed. The work derives conditions for synaptic time constants based on experimental results and gives conditions on the resting state stability. Further the power spectrum of Local Field Potentials and EEG generated by the neural activity is derived analytically and allow for the detailed study of bi-spectral power changes. We find bi-phasic power changes both in monostable and bistable system regime, affirming the omnipresence of bi-spectral power changes in anesthesia. Further the work gives conditions for the strong increase of power in the δ-frequency band for large propofol concentrations as observed in experiments. Springer Science+Business Media B.V., 2009 General anesthesia nationallicence Neural fields nationallicence EEG nationallicence Power spectrum nationallicence Hutt Axel INRIA CR Nancy - Grand Est, CS20101, 54603, Villers-ls-Nancy Cedex, France aut Longtin Andre Department of Physics, University of Ottawa, 150 Louis Pasteur, K1N-6N5, Ottawa, ON, Canada aut Cognitive Neurodynamics Springer Netherlands 4/1(2010-03-01), 37-59 1871-4080 4:1<37 2010 4 11571 https://doi.org/10.1007/s11571-009-9092-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11571-009-9092-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hutt Axel INRIA CR Nancy - Grand Est, CS20101, 54603, Villers-ls-Nancy Cedex, France aut NATIONALLICENCE 700 1- Longtin Andre Department of Physics, University of Ottawa, 150 Louis Pasteur, K1N-6N5, Ottawa, ON, Canada aut NATIONALLICENCE 773 0- Cognitive Neurodynamics Springer Netherlands 4/1(2010-03-01), 37-59 1871-4080 4:1<37 2010 4 11571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer