caa a22 4500 44529504X CHVBK 20180317142539.0 cr unu---uuuuu 170323e20101201xx s 000 0 eng 10.1007/s11571-010-9129-6 doi (NATIONALLICENCE)springer-10.1007/s11571-010-9129-6 The modeling and simulation of visuospatial working memory [Elektronische Daten] [Lina Liang, Rubin Wang, Zhikang Zhang] Camperi and Wang (Comput Neurosci 5:383-405, 1998) presented a network model for working memory that combines intrinsic cellular bistability with the recurrent network architecture of the neocortex. While Fall and Rinzel (Comput Neurosci 20:97-107, 2006) replaced this intrinsic bistability with a biological mechanism-Ca2+ release subsystem. In this study, we aim to further expand the above work. We integrate the traditional firing-rate network with Ca2+ subsystem-induced bistability, amend the synaptic weights and suggest that Ca2+ concentration only increase the efficacy of synaptic input but has nothing to do with the external input for the transient cue. We found that our network model maintained the persistent activity in response to a brief transient stimulus like that of the previous two models and the working memory performance was resistant to noise and distraction stimulus if Ca2+ subsystem was tuned to be bistable. Springer Science+Business Media B.V., 2010 Working memory nationallicence Bistability nationallicence Computational model nationallicence Calcium signaling nationallicence Liang Lina Institute for Cognitive Neurodynamics, School of Information Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, People's Republic of China aut Wang Rubin Institute for Cognitive Neurodynamics, School of Information Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, People's Republic of China aut Zhang Zhikang Institute for Cognitive Neurodynamics, School of Information Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, People's Republic of China aut Cognitive Neurodynamics Springer Netherlands 4/4(2010-12-01), 359-366 1871-4080 4:4<359 2010 4 11571 https://doi.org/10.1007/s11571-010-9129-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11571-010-9129-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liang Lina Institute for Cognitive Neurodynamics, School of Information Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Wang Rubin Institute for Cognitive Neurodynamics, School of Information Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Zhikang Institute for Cognitive Neurodynamics, School of Information Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, People's Republic of China aut NATIONALLICENCE 773 0- Cognitive Neurodynamics Springer Netherlands 4/4(2010-12-01), 359-366 1871-4080 4:4<359 2010 4 11571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer