caa a22 4500 445295155 CHVBK 20180317142539.0 cr unu---uuuuu 170323e20101201xx s 000 0 eng 10.1007/s11657-010-0043-7 doi (NATIONALLICENCE)springer-10.1007/s11657-010-0043-7 Determinants of bone strength and fracture incidence in adult Finns: Cardiovascular Risk in Young Finns Study (the GENDI pQCT study) [Elektronische Daten] [Marika Laaksonen, Harri Sievänen, Sanna Tolonen, Vera Mikkilä, Leena Räsänen, Jorma Viikari, Terho Lehtimäki, Mika Kähönen, Olli Raitakari] Summary: Peripheral bone strength and fracture risk were studied in young adult Finns. Peripheral bone measures were associated with risk factors of osteoporosis in young adults and discriminated between those with and without low-energy fractures. In men, trabecular bone loss at peripheral bone sites starts before the age of 40years. Purpose: This is a cross-sectional study of the determinants of bone strength and fracture risk in young Finns using peripheral quantitative computed tomography (pQCT) and quantitative ultrasound (QUS). Methods: pQCT scans were performed in 1,884 subjects at distal and shaft sites of non-dominant radius and left tibia, and QUS measures (n = 1,415) at the left calcaneus. Lifestyle factors and medical conditions affecting bone health were assessed with questionnaires. Results: In men, the youngest age cohort had the lowest trabecular volumetric bone mineral density (vBMD) at radius and tibia (difference between the youngest and the oldest, 4.4% and 5.6%, respectively, P < 0.001) and lowest speed of ultrasound at the calcaneus (difference 0.5%, P = 0.016). In women, bone traits did not differ by age groups. When sexes were pooled, underweight (relative risk (RR) = 2.95, P < 0.001), excess alcohol intake (1.52, P = 0.036), smoking (1.29, P = 0.025), Crohn's disease or inflammatory bowel syndrome (2.43, P = 0.016), epilepsy (2.54, P = 0.011), use of corticosteroids (2.01, P < 0.001) and inactivity (1.34, P = 0.045) increased the risk of low trabecular vBMD. RRs for low-energy fractures were excess alcohol intake (2.58, P = <0.001), anorexia (3.74, P = 0.041) and hypogonadism (2.08, P = 0.015). Same risk factors predicted BMD and fractures in both sexes. Trabecular bone mineral content, vBMD and bone strength index showed greatest differences (4-9%; P < 0.05) between those with and without low-energy fractures. Conclusions: Peripheral QCT traits are associated with common risk factors of osteoporosis in young Finns and discriminate between those with and without low-energy fractures. In men, trabecular bone loss at peripheral bone sites starts before the age of 40years. International Osteoporosis Foundation and National Osteoporosis Foundation, 2010 Osteoporosis nationallicence Fractures nationallicence pQCT nationallicence Bone strength nationallicence Young Finns Study nationallicence Laaksonen Marika Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut Sievänen Harri UKK Institute, Tampere, Finland aut Tolonen Sanna Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut Mikkilä Vera Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut Räsänen Leena Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut Viikari Jorma Department of Medicine, Turku University Central Hospital, Turku, Finland aut Lehtimäki Terho Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland aut Kähönen Mika Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland aut Raitakari Olli Department of Clinical Physiology, Turku University Central Hospital, Turku, Finland aut Archives of Osteoporosis Springer-Verlag 5/1-2(2010-12-01), 119-130 1862-3522 5:1-2<119 2010 5 11657 https://doi.org/10.1007/s11657-010-0043-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11657-010-0043-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Laaksonen Marika Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Sievänen Harri UKK Institute, Tampere, Finland aut NATIONALLICENCE 700 1- Tolonen Sanna Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Mikkilä Vera Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Räsänen Leena Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Viikari Jorma Department of Medicine, Turku University Central Hospital, Turku, Finland aut NATIONALLICENCE 700 1- Lehtimäki Terho Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland aut NATIONALLICENCE 700 1- Kähönen Mika Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland aut NATIONALLICENCE 700 1- Raitakari Olli Department of Clinical Physiology, Turku University Central Hospital, Turku, Finland aut NATIONALLICENCE 773 0- Archives of Osteoporosis Springer-Verlag 5/1-2(2010-12-01), 119-130 1862-3522 5:1-2<119 2010 5 11657 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer