caa a22 4500 445295279 CHVBK 20180317142540.0 cr unu---uuuuu 170323e20101201xx s 000 0 eng 10.1007/s11657-010-0039-3 doi (NATIONALLICENCE)springer-10.1007/s11657-010-0039-3 Health-related quality of life with vertebral fracture, lumbar spondylosis and knee osteoarthritis in Japanese men: the ROAD study [Elektronische Daten] [Shigeyuki Muraki, Toru Akune, Hiroyuki Oka, Yoshio En-yo, Munehito Yoshida, Akihiko Saika, Takao Suzuki, Hideyo Yoshida, Hideaki Ishibashi, Fumiaki Tokimura, Seizo Yamamoto, Kozo Nakamura, Hiroshi Kawaguchi, Noriko Yoshimura] Summary: This study examined associations of VFx, lumbar spondylosis and knee OA with QOL in 767 men over 40years old from the ROAD study (mean, 69.7years.). Multiple regression analysis showed VFx and knee OA as significantly associated with lower PCS scores, but lumbar spondylosis was not. Purpose: Little data have been accumulated regarding associations of vertebral fracture (VFx), lumbar spondylosis and knee osteoarthritis (OA) with quality of life (QOL) in men. The purpose of the present study is to clarify the impact of these diseases on QOL parameters such as the Medical Outcomes Study Short Form 8 (SF-8) and the EuroQOL (EQ-5D). In addition, to provide greater insight into the magnitude of QOL loss, a comparison was made with cerebral stroke. Methods: From the 3,040 participants in the ROAD study, this study analyzed 767 men over 40years who had completed the questionnaires (mean, 69.7years.). Vertebral fracture was assessed by lateral radiography of the lumbar spine. Lumbar spondylosis and knee OA were defined as Kellgren/Lawrence grade ≥3. Cerebral stroke was assessed by self-report. Results: Multiple regression analysis after adjustments for age, body mass index and presence of the above four diseases showed VFx was significantly associated with lower scores in physical function (PF), role physical (RP), bodily pain (BP) and vitality (VT) domains as well as physical component summary (PCS). Knee OA were significantly associated with lower scores in PF, RP, BP and PCS scores. Lumbar spondylosis was not associated with any domains of the SF-8. Lumbar spondylosis and knee OA were significantly associated with EQ-5D utility scores, but VFx was not. The impact for VFx on BP, VT and PCS scores was larger than cerebral stroke. Conclusions: This study revealed that VFx and knee OA impaired physical QOL in men, rather than lumbar spondylosis. International Osteoporosis Foundation and National Osteoporosis Foundation, 2010 Quality of life nationallicence Vertebral fracture nationallicence Lumbar spondylosis nationallicence Knee osteoarthritis nationallicence Men nationallicence Muraki Shigeyuki Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Hongo 7-3-1, Bunkyo, 113-8655, Tokyo, Japan aut Akune Toru Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Hongo 7-3-1, Bunkyo, 113-8655, Tokyo, Japan aut Oka Hiroyuki Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut En-yo Yoshio Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan aut Yoshida Munehito Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan aut Saika Akihiko Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan aut Suzuki Takao Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Yoshida Hideyo Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Ishibashi Hideaki Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Tokimura Fumiaki Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Yamamoto Seizo Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Nakamura Kozo Department of Sensory and Motor System Medicine, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut Kawaguchi Hiroshi Department of Sensory and Motor System Medicine, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut Yoshimura Noriko Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut Archives of Osteoporosis Springer-Verlag 5/1-2(2010-12-01), 91-99 1862-3522 5:1-2<91 2010 5 11657 https://doi.org/10.1007/s11657-010-0039-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11657-010-0039-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muraki Shigeyuki Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Hongo 7-3-1, Bunkyo, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Akune Toru Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Hongo 7-3-1, Bunkyo, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Oka Hiroyuki Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- En-yo Yoshio Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan aut NATIONALLICENCE 700 1- Yoshida Munehito Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan aut NATIONALLICENCE 700 1- Saika Akihiko Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan aut NATIONALLICENCE 700 1- Suzuki Takao Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Yoshida Hideyo Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishibashi Hideaki Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Tokimura Fumiaki Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamamoto Seizo Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Kozo Department of Sensory and Motor System Medicine, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawaguchi Hiroshi Department of Sensory and Motor System Medicine, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Yoshimura Noriko Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, the University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 773 0- Archives of Osteoporosis Springer-Verlag 5/1-2(2010-12-01), 91-99 1862-3522 5:1-2<91 2010 5 11657 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer