caa a22 4500 445297433 CHVBK 20180317142546.0 cr unu---uuuuu 170323e20100101xx s 000 0 eng 10.1007/s12070-010-0002-z doi (NATIONALLICENCE)springer-10.1007/s12070-010-0002-z Comparative study of two cefazolin prophylactic protocols in oncologic surgery of the larynx: A randomized trial [Elektronische Daten] [Mohammad Taghy, Khorsandi Ashtiani, Mohammad Sadeghi, Babak Saedi, Gilda Givechi] Objective: Patients who need major head and neck surgery like laryngectomy are at risk of postoperative wound infection. Although the role of antibiotics in prophylaxis of clean contaminated head and neck surgery has been well documented, controversy exists in the optimal antibiotic regimen. Methods: In two tertiary referral hospitals (Imam Khomeini and Amir Alam hospital), 90 patients undergoing laryngectomy were prospectively randomized into two groups receiving cefazolin perioperative prophylaxis either for 2 days or for 5 days from June 2004 to March 2006. Then patients were blindly examined for the development of wound infection. Results: No wound infection was detected in either group. Two (4.4%) mucocutaneous fistula occurred in the 2-day group, and 3 (6.7%) in the 5-day group. There was no statistically significant difference in the infection rate between two groups. Conclusion: We conclude that a 2-day perioperative cefazolin prophylaxis is equally effective as longer therapies. The increased morbidity and cost of the latter are in favor of the 2-day prophylactic regimen. Association of Otolaryngologists of India, 2010 Clean contaminated nationallicence Laryngeal cancer nationallicence Head and neck surgery nationallicence Wound infection nationallicence Antibiotic nationallicence Taghy Mohammad Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Ashtiani Khorsandi Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Sadeghi Mohammad Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Saedi Babak Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Givechi Gilda Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Indian Journal of Otolaryngology and Head & Neck Surgery Springer-Verlag 62/1(2010-01-01), 55-59 0019-5421 62:1<55 2010 62 12070 https://doi.org/10.1007/s12070-010-0002-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12070-010-0002-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taghy Mohammad Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Ashtiani Khorsandi Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Sadeghi Mohammad Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Saedi Babak Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Givechi Gilda Department of Otolaryngology — Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 773 0- Indian Journal of Otolaryngology and Head & Neck Surgery Springer-Verlag 62/1(2010-01-01), 55-59 0019-5421 62:1<55 2010 62 12070 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer