caa a22 4500 445297441 CHVBK 20180317142546.0 cr unu---uuuuu 170323e20100101xx s 000 0 eng 10.1007/s12070-010-0011-y doi (NATIONALLICENCE)springer-10.1007/s12070-010-0011-y Myeloperoxydase activity in the pathogenesis of cholesteatoma [Elektronische Daten] [Özlem Çelebi, Mustafa Paksoy, Sedat Aydin, Arif Şanlı, Ömer Taşdemir, Aylin Gül] Objective: The aim of this study was to determine the effect of myeloperoxydase (MPO) in bone destruction in patients of chronic otitis media (COM) with cholesteatoma by immtino-histochemical staining and to conclude the possible relationship between bone destruction in patients with cholesteatoma accompanied with COM and MPO activity. Methods: The study was conducted on a total number of 81 patients where 51 of the patients were enrolled in the "patient group” and 30 of the patients were enrolled in the "control group” whom were operated due to otitis media. MPO positivism was monitored when a cytoplasmic staining process was performed. Results: Meanwhile, a significant difference is present at a statistically advanced level between the MPO levels of groups (p = 0.001; p < 0.01). However, MPO activity is absent in patients included in the control group or it can be observed at a very slight level. A moderate level or intense level of activity can be observed in patients enrolled in the study group. Excluding the destruction at the dura, all findings related with the middle ear and the erosion of the mastoid cavity and MPO activity indicated a statistically significant difference (p < 0.05). According to the destruction at the wall of the dura bone, distribution of MPO activity did not display a statistically meaningful difference (p > 0.05). Conclusion: In this study, we investigated the relationship between MPO level and bone destruction and found a significant level of correlation among the fore said. A new era may be opened in the treatment of cholesteatoma when preoperative MPO levels are determined and adequate information is obtained related with bone erosion. Association of Otolaryngologists of India, 2010 Myeloperoxydase nationallicence Cholesteatoma nationallicence Chronic otitis media nationallicence Çelebi Özlem Rize Government Hospital, Rize, Turkey aut Paksoy Mustafa Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut Aydin Sedat Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut Şanlı Arif Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut Taşdemir Ömer Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut Gül Aylin Department of Pathology, Kartal Training and Research Hospital, Istanbul, Turkey aut Indian Journal of Otolaryngology and Head & Neck Surgery Springer-Verlag 62/1(2010-01-01), 32-35 0019-5421 62:1<32 2010 62 12070 https://doi.org/10.1007/s12070-010-0011-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12070-010-0011-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Çelebi Özlem Rize Government Hospital, Rize, Turkey aut NATIONALLICENCE 700 1- Paksoy Mustafa Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Aydin Sedat Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Şanlı Arif Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Taşdemir Ömer Department of ENT, Kartal Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Gül Aylin Department of Pathology, Kartal Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 773 0- Indian Journal of Otolaryngology and Head & Neck Surgery Springer-Verlag 62/1(2010-01-01), 32-35 0019-5421 62:1<32 2010 62 12070 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer