caa a22 4500 445298324 CHVBK 20180317142549.0 cr unu---uuuuu 170323e20100501xx s 000 0 eng 10.1007/s12013-010-9080-5 doi (NATIONALLICENCE)springer-10.1007/s12013-010-9080-5 Digitalis Does not Improve Left Atrial Mechanical Dysfunction After Successful Electrical Cardioversion of Chronic Atrial Fibrillation [Elektronische Daten] [Wang Yujing, Huang Congxin, Yang Shaning, Jin Lijun, Hu Xiaojun, Wu Gang, Xie Qiang] This study was designed to investigate whether administration of digitalis could improve mechanical function of left atrial appendage (LAA) and left atrium prospectively in patients with atrial stunning. Fifty-four consecutive patients in whom atrial stunning was observed immediately after cardioversion of chronic atrial fibrillation (AF) were randomized into digitalis or control group for 1 week following cardioversion. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) were performed prior to, immediately following, 1day after and 1week after cardioversion to measure transmitral flow velocity and LAA flow velocity. Electrical cardioversion of AF elicited significantly slower left atrial appendage peak emptying velocity (LAA-PEV) and peak filling velocity (LAA-PFV) immediately following cardioversion in both groups. 1 day post cardioversion, there were no significant differences in transmitral E wave, A wave, E/A ratio, LAA-PEV, LAA-PFV or left atrial appendage ejection fraction (LAA-EF) between digitalis and control groups. 1 week post cardioversion, no significant differences were found in transmitral E wave, A wave, E/A ratio, LAA-PEV, LAA-PFV or LAA-EF between the two groups. The occurrence rates of spontaneous echo contrast were not significantly different between digitalis and control groups one day and one week post cardioversion. In conclusion, digitalis did not improve left atrial and appendage mechanical dysfunction following cardioversion of chronic AF. Digitalis did not prevent the development of spontaneous echo contrast in left atrial chamber and appendage. This may be due to the fact that digitalis aggravates intracellular calcium overload induced by chronic AF and has a negative effect on ventricular rate. Springer Science+Business Media, LLC, 2010 Digitalis nationallicence Atrial fibrillation nationallicence Cardioversion nationallicence Myocardial stunning nationallicence Yujing Wang Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut Congxin Huang Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut Shaning Yang Cardiovascular Department, The First People's Hospital of Jingzhou, The First Affiliated Hospital of Changjiang University, Hangkong Road 8, Shashi Distict, 434000, Jingzhou, Hubei Province, China aut Lijun Jin Cardiovascular Department, The First People's Hospital of Jingzhou, The First Affiliated Hospital of Changjiang University, Hangkong Road 8, Shashi Distict, 434000, Jingzhou, Hubei Province, China aut Xiaojun Hu Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut Gang Wu Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut Qiang Xie Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut Cell Biochemistry and Biophysics Humana Press Inc 57/1(2010-05-01), 27-34 1085-9195 57:1<27 2010 57 12013 https://doi.org/10.1007/s12013-010-9080-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12013-010-9080-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yujing Wang Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Congxin Huang Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Shaning Yang Cardiovascular Department, The First People's Hospital of Jingzhou, The First Affiliated Hospital of Changjiang University, Hangkong Road 8, Shashi Distict, 434000, Jingzhou, Hubei Province, China aut NATIONALLICENCE 700 1- Lijun Jin Cardiovascular Department, The First People's Hospital of Jingzhou, The First Affiliated Hospital of Changjiang University, Hangkong Road 8, Shashi Distict, 434000, Jingzhou, Hubei Province, China aut NATIONALLICENCE 700 1- Xiaojun Hu Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Gang Wu Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Qiang Xie Division of Cardiology, Renmin's Hospital of Wuhan University, Ziyang Road, Wuchang District, 430060, Wuhan, Hubei Province, China aut NATIONALLICENCE 773 0- Cell Biochemistry and Biophysics Humana Press Inc 57/1(2010-05-01), 27-34 1085-9195 57:1<27 2010 57 12013 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer