caa a22 4500 445298405 CHVBK 20180317142549.0 cr unu---uuuuu 170323e20100901xx s 000 0 eng 10.1007/s12013-010-9088-x doi (NATIONALLICENCE)springer-10.1007/s12013-010-9088-x Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds [Elektronische Daten] [Ria Ramoutar, Julia Brumaghim] Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of efficacy are the focus of much current research. This review discusses the ability of inorganic selenium compounds, such as selenite, and selenate, to prevent damage from reactive oxygen species as well as their ability to promote cell death by reactive oxygen species generation. Oxo-sulfur and selenium compounds, such as allicin, dimethyl sulfone, methionine sulfoxide, and methylselenenic acid also have similar abilities to act as both antioxidants and pro-oxidants, but the mechanisms for these behaviors are distinctly different from those of the inorganic selenium compounds. The antioxidant and pro-oxidant properties of these small-molecule sulfur and selenium compounds are extremely complex and often greatly depend on experimental conditions, which may explain contradictory literature reports of their efficacy. Springer Science+Business Media, LLC, 2010 Antioxidant mechanisms nationallicence Anticancer mechanisms nationallicence Inorganic selenium compounds nationallicence Oxo-sulfur compounds nationallicence Oxo-selenium compounds nationallicence Reactive oxygen species nationallicence Selenium speciation nationallicence ACSO : Alliin, S-allyl-L-cysteine sulfoxide nationallicence AGE : Aged garlic extracts nationallicence AIDS : Acquired immune deficiency syndrome nationallicence ARC : AIDS-related complex nationallicence [Cu(bipy)2]+ : Copper (I) bypyridine nationallicence DMSO : Dimethyl sulfoxide nationallicence DNA : Deoxyribonucleic acid nationallicence [Fe(EDTA)]2− : Iron(II) ethylenediaminetetraacetic acid nationallicence FMO : Flavin-containing monooxygenase nationallicence GPx : Glutathione peroxidase nationallicence GSH : Glutathione nationallicence GSSeSG : Selenoglutathione nationallicence GSSe− : Selenopersulfide anion nationallicence GSSH : Glutathione disulfide nationallicence H2O2 : Hydrogen peroxide nationallicence H2Se : Hydrogen selenide nationallicence HDL : High density lipoprotein nationallicence HIV : Human immunodeficiency virus nationallicence HSC-3 : Human oral squamous carcinoma cells nationallicence IC50 : Concentration required for 50% inhibition of biological activity nationallicence LDL : Low-density lipoprotein nationallicence MeCysSO nationallicence MCSO : Methylcysteine sulfoxide, S-methyl-L-cysteine sulfoxide, methiin nationallicence Me2SO2 : Dimethyl sulfone nationallicence methylsulfonyl methane nationallicence Met : Methionine nationallicence MePhSO : Methyl phenyl sulfoxide nationallicence MetSO : Methionine sulfoxide nationallicence MetSeO : Methionine selenoxide nationallicence MMTS : Methyl methane thiosulfonate nationallicence MSeA : Methylseleninic acid nationallicence Msr : Methionine sulfoxide reductase nationallicence MsrA : Methionine sulfoxide reductase A nationallicence MsrB : Methionine sulfoxide reductase B nationallicence NADH : Reduced nicotinamide adenine dinucleotide nationallicence NADP : Nictotinamide adenine dinucleotide phosphate nationallicence NADPH : Reduced nicotinamide adenine dinucleotide phosphate nationallicence Na2Se : Sodium selenide nationallicence Na2SeO3 : Sodium selenite nationallicence Na2SeO4 : Sodium selenate nationallicence 3O2 : Triplet oxygen nationallicence O2•− : Superoxide anion radical nationallicence •OH : Hydroxyl radical nationallicence ONOOH : Peroxynitrous acid nationallicence PCSO : Propiin, S-propyl-L-cysteine sulfoxide nationallicence PhSO : Phenyl sulfoxide nationallicence RDA : Recommended daily allowance nationallicence RNS : Reactive nitrogen species nationallicence ROS : Reactive oxygen species nationallicence RSSeSR : Selenotrisulfide nationallicence SAR : Seasonal allergy rhinitis nationallicence Se0 : Selenium (elemental) nationallicence SeCys : Selenocysteine nationallicence SeMet : Selenomethionine nationallicence SELECT : Selenium and Vitamin E Cancer Prevention Trial nationallicence SeO2 : Selenium dioxide nationallicence SOD : Superoxide dismutase nationallicence TEMPO : 2,2,6,6-Tetramethylpiperdine-1-oxyl nationallicence TPCSO : Isoalliin, S-trans-1-propenyl-L-cysteine sulfoxide nationallicence Ramoutar Ria Chemistry Department, Clemson University, 29634, Clemson, SC, USA aut Brumaghim Julia Chemistry Department, Clemson University, 29634, Clemson, SC, USA aut Cell Biochemistry and Biophysics Humana Press Inc 58/1(2010-09-01), 1-23 1085-9195 58:1<1 2010 58 12013 https://doi.org/10.1007/s12013-010-9088-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12013-010-9088-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramoutar Ria Chemistry Department, Clemson University, 29634, Clemson, SC, USA aut NATIONALLICENCE 700 1- Brumaghim Julia Chemistry Department, Clemson University, 29634, Clemson, SC, USA aut NATIONALLICENCE 773 0- Cell Biochemistry and Biophysics Humana Press Inc 58/1(2010-09-01), 1-23 1085-9195 58:1<1 2010 58 12013 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer