caa a22 4500 445298413 CHVBK 20180317142549.0 cr unu---uuuuu 170323e20100901xx s 000 0 eng 10.1007/s12013-010-9092-1 doi (NATIONALLICENCE)springer-10.1007/s12013-010-9092-1 Mahmoud Sherif Biophysics and Laser Science Unit, Research Institute of Ophthalmology, P.O. Box 90, Giza, Egypt aut The Impact of Elevated Blood Glycemic Level of Patients with Type 2 Diabetes Mellitus on the Erythrocyte Membrane: FTIR Study [Elektronische Daten] [Sherif Mahmoud] In developed countries, medical awareness about the disease and how to deal with it is less acknowledged. With diabetes mellitus the situation becomes more serious due to the fact that it affects nearly all parts of the body and may lead to loss of vision. In this study, the variation of blood glucose level of type 2 diabetic patients was considered, and its effect(s) on their blood erythrocyte membranes was studied by Fourier transform infrared spectroscopy. Patients with type 2 diabetes mellitus were classified into two groups with mean fasting blood glucose level of 185mg/dl (D-185 group) and 285mg/dl (D-285 group). For comparison, healthy individuals were involved where their mean fasting blood glucose level is 86mg/dl. Type 2 diabetes mellitus was found to induce change in the lipid and protein components and causing some important structural changes in the protein secondary structure with change in the β-sheet and β-turn structures at D-285mg/dl group. Erythrocyte membrane disorder was increased associated with restriction in the vibrational motion around the phospholipids interface region. Springer Science+Business Media, LLC, 2010 Diabetes mellitus nationallicence Erythrocyte membrane nationallicence FTIR nationallicence Protein nationallicence Lipids nationallicence Blood nationallicence Cell Biochemistry and Biophysics Humana Press Inc 58/1(2010-09-01), 45-51 1085-9195 58:1<45 2010 58 12013 https://doi.org/10.1007/s12013-010-9092-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12013-010-9092-1 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Mahmoud Sherif Biophysics and Laser Science Unit, Research Institute of Ophthalmology, P.O. Box 90, Giza, Egypt aut NATIONALLICENCE 773 0- Cell Biochemistry and Biophysics Humana Press Inc 58/1(2010-09-01), 45-51 1085-9195 58:1<45 2010 58 12013 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer