caa a22 4500 445298561 CHVBK 20180317142550.0 cr unu---uuuuu 170323e20101101xx s 000 0 eng 10.1007/s12013-010-9094-z doi (NATIONALLICENCE)springer-10.1007/s12013-010-9094-z Treatment of Trigeminal Neuralgia with Percutaneous Glycerol Injection into Meckel's Cavity: Experience in 4012 Patients [Elektronische Daten] [LiZhao Chen, MinHui Xu, YongWen Zou] Percutaneous glycerol injection into Meckel's cavity is widely used to treat trigeminal neuralgia. Reports published to date summarized clinical experiences in small or intermediately sized groups of patients. The efficacy of this procedure in a large group of patients has not been evaluated so far. From December 1983 to November 2008, patients with primary trigeminal neuralgia were treated in our clinic using percutaneous glycerol injection into Meckel's cavity which was conducted according to the Hakanson's anterior puncture method with some modifications. In total, 4012 patients (2205 female) with a mean age of 56.5 (23-87) years were treated. The majority of patients (99.23%) experienced unilateral pain, while a small cohort of patients (31; 0.77%) had bilateral pain. The immediate success rate of the procedure was 97.1%. There was a significant (P<0.01) positive correlation between the presence of cerebrospinal fluid (CSF) outflow and the curative effect. Follow-up was done in 3157 patients for the period of 1-25years. The long-term success rate was 81.18%. No serious adverse effects were observed. The procedure is very effective and applicable to a wide variety of patients with trigeminal neuralgia. The presence of CSF outflow during puncture predicts better immediate and long-term outcomes. Springer Science+Business Media, LLC, 2010 Trigeminal neuralgia nationallicence Glycerol injection nationallicence Meckel's cavity nationallicence Efficacy nationallicence Long-term success nationallicence Chen LiZhao Department of NeuroSurgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, 10#, Changjiang Branch, Daping, Yuzhong District, 400042, Chongqing, China aut Xu MinHui Department of NeuroSurgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, 10#, Changjiang Branch, Daping, Yuzhong District, 400042, Chongqing, China aut Zou YongWen Department of NeuroSurgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, 10#, Changjiang Branch, Daping, Yuzhong District, 400042, Chongqing, China aut Cell Biochemistry and Biophysics Humana Press Inc 58/2(2010-11-01), 85-89 1085-9195 58:2<85 2010 58 12013 https://doi.org/10.1007/s12013-010-9094-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12013-010-9094-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen LiZhao Department of NeuroSurgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, 10#, Changjiang Branch, Daping, Yuzhong District, 400042, Chongqing, China aut NATIONALLICENCE 700 1- Xu MinHui Department of NeuroSurgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, 10#, Changjiang Branch, Daping, Yuzhong District, 400042, Chongqing, China aut NATIONALLICENCE 700 1- Zou YongWen Department of NeuroSurgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, 10#, Changjiang Branch, Daping, Yuzhong District, 400042, Chongqing, China aut NATIONALLICENCE 773 0- Cell Biochemistry and Biophysics Humana Press Inc 58/2(2010-11-01), 85-89 1085-9195 58:2<85 2010 58 12013 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer