caa a22 4500 445298790 CHVBK 20180317142550.0 cr unu---uuuuu 170323e20100601xx s 000 0 eng 10.1007/s11864-010-0117-1 doi (NATIONALLICENCE)springer-10.1007/s11864-010-0117-1 Rajdev Lakshmi Jack D. Weiler Hospital of The Albert Einstein College of Medicine, Montefiore Medical Center, 1825 Eastchester Road Rm# 2S-50, 10461, Bronx, NY, USA aut Treatment Options for Surgically Resectable Gastric Cancer [Elektronische Daten] [Lakshmi Rajdev] Opinion statement: Surgery is the only curative therapy for gastric cancer. The standard recommendations for resectable gastric adenocarcinoma are free-margin surgery with at least D1 resection and the removal of a minimum of 15 lymph nodes. The overall 5-year survival rate for resected gastric patients remains poor due to locoregional recurrence. The results of a large North American study (Gastrointestinal Cancer Intergroup Trial INT 0116) reported that postoperative chemoradiotherapy conferred a survival advantage compared with surgery alone, which led to the regimen being adopted as a standard of care. More recently the MAGIC/UK Medical Research Council (MRC) trial demonstrated that perioperative chemotherapy resulted in an improvement in overall survival and progression free survival. Thus, two successful strategies are available to improve outcomes in patients with localized gastric cancer. This article reviews data on adjuvant and perioperative treatment modalities for gastric cancer. The article discusses ongoing randomized adjuvant and perioperative trials that are designed to optimize chemotherapy regimens and also investigate combinations of chemotherapy and biologic agents. It is important to understand the mechanisms or pathways involved in gastric cancer development and metastasis. Identification of novel molecules pivotal to tumor biology may lead to new therapeutic approaches for this malignancy. Springer Science+Business Media, LLC, 2010 Current Treatment Options in Oncology Springer US; http://www.springer-ny.com 11/1-2(2010-06-01), 14-23 1527-2729 11:1-2<14 2010 11 11864 https://doi.org/10.1007/s11864-010-0117-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11864-010-0117-1 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rajdev Lakshmi Jack D. Weiler Hospital of The Albert Einstein College of Medicine, Montefiore Medical Center, 1825 Eastchester Road Rm# 2S-50, 10461, Bronx, NY, USA aut NATIONALLICENCE 773 0- Current Treatment Options in Oncology Springer US; http://www.springer-ny.com 11/1-2(2010-06-01), 14-23 1527-2729 11:1-2<14 2010 11 11864 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer