caa a22 4500 445299045 CHVBK 20180317142551.0 cr unu---uuuuu 170323e20100701xx s 000 0 eng 10.1007/s11940-010-0081-x doi (NATIONALLICENCE)springer-10.1007/s11940-010-0081-x Raizer Jeffrey Feinberg School of Medicine, Department of Neurology, Northwestern University, 710 North Lake Shore Drive, Abbott Hall, Room 1123, 60611, Chicago, IL, USA aut Meningiomas [Elektronische Daten] [Jeffrey Raizer] Opinion statement: Meningiomas are extra-axial dural-based tumors. They are the most common intracranial tumors, occur in mid to late life, and have a female predilection. Symptoms are a function of location. Meningiomas are usually benign, but atypical and malignant forms exist. Treatment is indicated for symptomatic lesions or when neurologic symptoms may shortly occur. Surgical resection can be curative; however, because of their location, some lesions are amenable only to partial resection. Radiation therapy is used for incompletely removed symptomatic lesions, lesions that are not surgically accessible, and small symptomatic lesions. For higher grade meningiomas, radiation is used after surgery. For lesions that recur or grow despite surgery and radiation, systemic chemotherapy can be tried. There is no optimal agent, but hydroxyurea is used most often with very modest success; hormonal approaches have not been successful. Targeting somatostatin receptors or receptor tyrosine kinases using novel agents appears to have some activity and is an area of clinical research. Springer Science+Business Media, LLC, 2010 Current Treatment Options in Neurology Current Science Inc. 12/4(2010-07-01), 360-368 1092-8480 12:4<360 2010 12 11940 https://doi.org/10.1007/s11940-010-0081-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11940-010-0081-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Raizer Jeffrey Feinberg School of Medicine, Department of Neurology, Northwestern University, 710 North Lake Shore Drive, Abbott Hall, Room 1123, 60611, Chicago, IL, USA aut NATIONALLICENCE 773 0- Current Treatment Options in Neurology Current Science Inc 12/4(2010-07-01), 360-368 1092-8480 12:4<360 2010 12 11940 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer