caa a22 4500 445299126 CHVBK 20180317142551.0 cr unu---uuuuu 170323e20100701xx s 000 0 eng 10.1007/s11940-010-0079-4 doi (NATIONALLICENCE)springer-10.1007/s11940-010-0079-4 New Antiepileptic Drugs: Lacosamide, Rufinamide, and Vigabatrin [Elektronische Daten] [Laura Strom, Susan Koh, Lauren Frey] Opinion statement: The treatment of epilepsy is complicated by the multiple seizure types and epilepsy syndromes needing therapy. In addition, seizures in up to 30% of epilepsy patients are resistant to available medications. The three newest antiepileptic medications (lacosamide, rufinamide, and vigabatrin) all putatively have novel mechanisms of action, which might increase the chance of treatment success in patients failing previous antiepilepsy drug trials and the chance of successful synergy with currently available medications. In our experience, all three drugs generally are well tolerated, although the risk for serious long-term complications with vigabatrin presents special challenges and precautions. Lacosamide is approved for the adjunctive therapy of complex partial seizures in adults and also is available in an intravenous formulation. Rufinamide is a new treatment option for seizures associated with Lennox-Gastaut syndrome, and although it is not FDA approved for partial seizures, it has shown efficacy for that indication as well. Vigabatrin has been approved in adults for drug-resistant complex partial seizures and in infants as a treatment option for infantile spasms. Springer Science+Business Media, LLC, 2010 Strom Laura The Children's Hospital, 13123 E 16th Avenue, 80045, Aurora, CO, USA aut Koh Susan The Children's Hospital, 13123 E 16th Avenue, 80045, Aurora, CO, USA aut Frey Lauren The Children's Hospital, 13123 E 16th Avenue, 80045, Aurora, CO, USA aut Current Treatment Options in Neurology Current Science Inc. 12/4(2010-07-01), 287-299 1092-8480 12:4<287 2010 12 11940 https://doi.org/10.1007/s11940-010-0079-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11940-010-0079-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Strom Laura The Children's Hospital, 13123 E 16th Avenue, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Koh Susan The Children's Hospital, 13123 E 16th Avenue, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Frey Lauren The Children's Hospital, 13123 E 16th Avenue, 80045, Aurora, CO, USA aut NATIONALLICENCE 773 0- Current Treatment Options in Neurology Current Science Inc 12/4(2010-07-01), 287-299 1092-8480 12:4<287 2010 12 11940 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer