caa a22 4500 445299215 CHVBK 20180317142551.0 cr unu---uuuuu 170323e20100901xx s 000 0 eng 10.1007/s11940-010-0086-5 doi (NATIONALLICENCE)springer-10.1007/s11940-010-0086-5 Meningococcal Meningitis [Elektronische Daten] [Ricardo Branco, Robert Tasker] Opinion statement: Meningococcal meningitis (MM) is the most common presentation of meningococcal disease and an important cause of morbidity and mortality worldwide. When MM is associated with shock, early recognition and treatment of shock is essential. No investigation should delay starting antibiotics once the diagnosis is suspected. Corticosteroids can be started at the same time as the antibiotics or just before, but this is not a specific recommendation for MM. Low-dose steroids should be used in meningococcal disease with refractory shock. Altered blood flow, cerebral edema, and raised intracranial pressure are problems that should be considered in all patients with MM and decreased consciousness level. When mechanical ventilation is required, the target carbon dioxide level is 4.0 to 4.5kPa, with avoidance of hypocapnia. Seizures, although not frequent, can occur in MM and require prompt treatment. Other treatments, such as mannitol and activated protein C, should be avoided. Potential new treatments requiring further investigation include neuroprotection with hypothermia or glycerol. Springer Science+Business Media, LLC, 2010 Branco Ricardo School of Clinical Medicine, Department of Paediatrics, Addenbrookes Hospital, University of Cambridge, Hills Road, Box116, CB2 2QQ, Cambridge, UK aut Tasker Robert School of Clinical Medicine, Department of Paediatrics, Addenbrookes Hospital, University of Cambridge, Hills Road, Box116, CB2 2QQ, Cambridge, UK aut Current Treatment Options in Neurology Current Science Inc. 12/5(2010-09-01), 464-474 1092-8480 12:5<464 2010 12 11940 https://doi.org/10.1007/s11940-010-0086-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11940-010-0086-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Branco Ricardo School of Clinical Medicine, Department of Paediatrics, Addenbrookes Hospital, University of Cambridge, Hills Road, Box116, CB2 2QQ, Cambridge, UK aut NATIONALLICENCE 700 1- Tasker Robert School of Clinical Medicine, Department of Paediatrics, Addenbrookes Hospital, University of Cambridge, Hills Road, Box116, CB2 2QQ, Cambridge, UK aut NATIONALLICENCE 773 0- Current Treatment Options in Neurology Current Science Inc 12/5(2010-09-01), 464-474 1092-8480 12:5<464 2010 12 11940 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer