caa a22 4500 445303441 CHVBK 20180317142605.0 cr unu---uuuuu 170323e20101201xx s 000 0 eng 10.1007/s12274-010-0056-y doi (NATIONALLICENCE)springer-10.1007/s12274-010-0056-y Preparation and control of the formation of single core and clustered nanoparticles for biomedical applications using a versatile amphiphilic diblock copolymer [Elektronische Daten] [Hongwei Chen, Julie Yeh, Liya Wang, Hafsa Khurshid, Nan Peng, Andrew Wang, Hui Mao] We report the application of a versatile diblock copolymer, poly(ethylene oxide)-b-poly(γ-methacryloxypropyl trimethoxysilane) (PEO-b-PγMPS), to prepare nanocrystals such as iron oxide nanoparticles or quantum dots, with either a single core or multi-core cluster, for biomedical applications. This amphiphilic copolymer comprises both a hydrophilic PEO segment and a hydrophobic segment with a "surface anchoring moiety” (the silane group) which can interact effectively with the hydrophobic nanocrystals through ligand exchange. One of the unique features of this work is that we can control the formation of either single core nanoparticles or multi-core nanoclusters by simply varying the conditions of ligand exchange and aging of the mixture of block copolymer and nanoparticles without needing to change the copolymer. The morphologies of the resulting single core nanoparticles or multi-core nanoclusters were confirmed by dynamic light scattering and transmission electron microscopy. The clustered nanoparticles exhibit enhanced physicochemical properties that are beyond those expected from a simple accumulation of individual nanoparticles. Additionally, the hybrid nanoparticles containing both magnetic iron oxide nanoparticles and optical quantum dots obtained using our strategy provide have combined magnetic and optical functionalities that allow for potential new and expanded biomedical applications, as demonstrated by their use for magnetic resonance imaging and biomarker-targeted cell imaging. Tsinghua University Press and Springer-Verlag Berlin Heidelberg, 2010 Magnetic nanoparticles nationallicence quantum dots nationallicence nanoparticle coating nationallicence copolymer nationallicence multifunctional nanoparticles nationallicence imaging nationallicence Chen Hongwei Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut Yeh Julie Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut Wang Liya Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut Khurshid Hafsa Department of Physics and Astronomy, University of Delaware, 19716, Newark, Delaware, USA aut Peng Nan Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut Wang Andrew Ocean NanoTech, LLC, 2143 Worth Lane, 72764, Springdale, Arkansas, USA aut Mao Hui Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut Nano Research Tsinghua Press 3/12(2010-12-01), 852-862 1998-0124 3:12<852 2010 3 12274 https://doi.org/10.1007/s12274-010-0056-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12274-010-0056-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Hongwei Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Yeh Julie Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Wang Liya Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Khurshid Hafsa Department of Physics and Astronomy, University of Delaware, 19716, Newark, Delaware, USA aut NATIONALLICENCE 700 1- Peng Nan Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Wang Andrew Ocean NanoTech, LLC, 2143 Worth Lane, 72764, Springdale, Arkansas, USA aut NATIONALLICENCE 700 1- Mao Hui Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, 30322, Atlanta, Georgia, USA aut NATIONALLICENCE 773 0- Nano Research Tsinghua Press 3/12(2010-12-01), 852-862 1998-0124 3:12<852 2010 3 12274 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer