caa a22 4500 445304235 CHVBK 20180317142607.0 cr unu---uuuuu 170323e20100901xx s 000 0 eng 10.1007/s13246-010-0030-8 doi (NATIONALLICENCE)springer-10.1007/s13246-010-0030-8 Non-targeted effects of ionising radiation and radiotherapy [Elektronische Daten] [Svetlana Sjostedt, Eva Bezak] Modern radiobiology is undergoing rapid change due to new discoveries contradicting the target concept which is currently used to predict dose-response relationships. Thus relatively recently discovered radiation-induced bystander effects (RIBEs), that include additional death, mutation and radio-adaptation in non-irradiated cells, change our understanding of the target concept and broadens its boundaries. This can be significant from a radioprotection point of view and also has the potential to reassess radiation damage models currently used in radiotherapy. This article reviews briefly the general concepts of RIBEs such as the proposed underlying mechanisms of signal induction and propagation, experimental approaches and biological end points used to investigate these phenomena. It also summarises several mathematical models currently proposed in an attempt to quantify RIBE. The main emphasis of this article is to review and highlight the potential impact of the bystander phenomena in radiotherapy. Australasian College of Physical Scientists and Engineers in Medicine, 2010 Biological responses to ionising radiation nationallicence Non-targeted effects nationallicence New paradigm in radiobiology nationallicence Radiation induced bystander effect nationallicence Radiotherapy nationallicence Sjostedt Svetlana Department of Medical Physics, Royal Adelaide Hospital, 5000, Adelaide, Australia aut Bezak Eva Department of Medical Physics, Royal Adelaide Hospital, 5000, Adelaide, Australia aut Australasian Physical & Engineering Sciences in Medicine Springer Netherlands 33/3(2010-09-01), 219-231 0158-9938 33:3<219 2010 33 13246 https://doi.org/10.1007/s13246-010-0030-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s13246-010-0030-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sjostedt Svetlana Department of Medical Physics, Royal Adelaide Hospital, 5000, Adelaide, Australia aut NATIONALLICENCE 700 1- Bezak Eva Department of Medical Physics, Royal Adelaide Hospital, 5000, Adelaide, Australia aut NATIONALLICENCE 773 0- Australasian Physical & Engineering Sciences in Medicine Springer Netherlands 33/3(2010-09-01), 219-231 0158-9938 33:3<219 2010 33 13246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer