caa a22 4500 445304251 CHVBK 20180317142607.0 cr unu---uuuuu 170323e20100901xx s 000 0 eng 10.1007/s13246-010-0026-4 doi (NATIONALLICENCE)springer-10.1007/s13246-010-0026-4 Modelling of tumour repopulation after chemotherapy [Elektronische Daten] [Loredana Marcu, Eva Bezak] While repopulation is a clinically observed phenomenon after radiotherapy, repopulation of tumour cells between cycles of chemotherapy is usually a neglected factor in cancer treatment. As the effect of both radiotherapy and chemotherapy on tumour cells is the same (attack on cancer cells), the response of the tumour to injury and cell loss from the two treatment methods should be similar, including repopulation. Cell recruitment is known to be a possible mechanism responsible for tumour regrowth after radiotherapy. The literature data regarding mechanisms of repopulation after chemotherapy is very limited. The current paper employs a Monte Carlo modelling approach to implement the pharmacokinetics of a widely used drug (cisplatin) into a previously developed virtual head and neck tumour and to study the effect of cisplatin on tumour regression and regrowth during treatment. The mechanism of cell recruitment was modelled by releasing various percentages (5-50%) of quiescent cells into the mitotic cycle after each chemotherapy cell kill. The onset of repopulation was also simulated, with both immediate onset and late onset of cell recruitment. Repopulation during chemotherapy, if occurring, is a highly potent phenomenon, similar to drug resistance, therefore it should not be neglected during treatment. Australasian College of Physical Scientists and Engineers in Medicine, 2010 Repopulation nationallicence Cisplatin nationallicence Recruitment nationallicence Chemotherapy nationallicence Marcu Loredana School of Chemistry and Physics, University of Adelaide, Adelaide, Australia aut Bezak Eva School of Chemistry and Physics, University of Adelaide, Adelaide, Australia aut Australasian Physical & Engineering Sciences in Medicine Springer Netherlands 33/3(2010-09-01), 265-270 0158-9938 33:3<265 2010 33 13246 https://doi.org/10.1007/s13246-010-0026-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s13246-010-0026-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marcu Loredana School of Chemistry and Physics, University of Adelaide, Adelaide, Australia aut NATIONALLICENCE 700 1- Bezak Eva School of Chemistry and Physics, University of Adelaide, Adelaide, Australia aut NATIONALLICENCE 773 0- Australasian Physical & Engineering Sciences in Medicine Springer Netherlands 33/3(2010-09-01), 265-270 0158-9938 33:3<265 2010 33 13246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer