caa a22 4500 445304405 CHVBK 20180317142608.0 cr unu---uuuuu 170323e20100601xx s 000 0 eng 10.1007/s13246-010-0024-6 doi (NATIONALLICENCE)springer-10.1007/s13246-010-0024-6 A statistical method (cross-validation) for bone loss region detection after spaceflight [Elektronische Daten] [Qian Zhao, Wenjun Li, Caixia Li, Philip Chu, John Kornak, Thomas Lang, Jiqian Fang, Ying Lu] Astronauts experience bone loss after the long spaceflight missions. Identifying specific regions that undergo the greatest losses (e.g. the proximal femur) could reveal information about the processes of bone loss in disuse and disease. Methods for detecting such regions, however, remains an open problem. This paper focuses on statistical methods to detect such regions. We perform statistical parametric mapping to get t-maps of changes in images, and propose a new cross-validation method to select an optimum suprathreshold for forming clusters of pixels. Once these candidate clusters are formed, we use permutation testing of longitudinal labels to derive significant changes. The Author(s), 2010 Suprathreshold nationallicence Cross-validation (CV) nationallicence Medical imaging nationallicence Permutation test nationallicence Zhao Qian Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China aut Li Wenjun Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut Li Caixia Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China aut Chu Philip Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut Kornak John Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut Lang Thomas Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut Fang Jiqian Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China aut Lu Ying Cooperative Studies Program Coordinating Center, VA Palo Alto Health Care System, 94304-1290, Palo Alto, CA, USA aut Australasian Physical & Engineering Sciences in Medicine Springer Netherlands 33/2(2010-06-01), 163-169 0158-9938 33:2<163 2010 33 13246 https://doi.org/10.1007/s13246-010-0024-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s13246-010-0024-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhao Qian Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China aut NATIONALLICENCE 700 1- Li Wenjun Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Li Caixia Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China aut NATIONALLICENCE 700 1- Chu Philip Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Kornak John Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Lang Thomas Department of Radiology and Biomedical Imaging, University of California, 94143-0946, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Fang Jiqian Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China aut NATIONALLICENCE 700 1- Lu Ying Cooperative Studies Program Coordinating Center, VA Palo Alto Health Care System, 94304-1290, Palo Alto, CA, USA aut NATIONALLICENCE 773 0- Australasian Physical & Engineering Sciences in Medicine Springer Netherlands 33/2(2010-06-01), 163-169 0158-9938 33:2<163 2010 33 13246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer