caa a22 4500 445306300 CHVBK 20180317142614.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00404-010-1389-1 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1389-1 Cetuximab monotherapy in advanced cervical cancer: a retrospective study with five patients [Elektronische Daten] [Linda Hertlein, Miriam Lenhard, Angela Kirschenhofer, Steffen Kahlert, Doris Mayr, Alexander Burges, Klaus Friese] Objective: Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited. Therefore, interest has increased in targeted therapeutics for the treatment of cervical cancer. Cetuximab, a monoclonal antibody, binds specifically to the epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor and other ligands. In cervical cancer the expression of EGFR is reported in up to 85% of the tumour cells. Therefore, Cetuximab monotherapy could be a new option in the treatment of patients with advanced cervical cancer. Study design: Five patients with advanced cervical cancer were treated with Cetuximab monotherapy as third- to fifthline therapy between 2005 and 2008 in our institution. The tumour stage at the time of diagnosis ranged between IIB and IVB. Cetuximab was applied with an initial loading dose of 400mg/m2 followed by a dose of 250mg/m2 weekly. Results: Only one patient (20%) had a stable disease, and the other four a progressive disease during Cetuximab monotherapy, after the RECIST criterias. Four out of five patients (80%) developed an acneiform rash as a common observed side effect of Cetuximab therapy. The median survival time from the beginning of the Cetuximab therapy was 8.6months. Conclusion: No advantage could be found in the treatment with Cetuximab monotherapy in patients with advanced cervical cancer in this study. Further studies are necessary to evaluate the significance of Cetuximab in the treatment of advanced cervical cancer. Springer-Verlag, 2010 Cetuximab nationallicence Advanced cervical cancer nationallicence EGFR antibody nationallicence Hertlein Linda Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut Lenhard Miriam Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut Kirschenhofer Angela Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut Kahlert Steffen Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut Mayr Doris Department of Pathology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Munich, Germany aut Burges Alexander Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut Friese Klaus Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 283/1(2011-01-01), 109-113 0932-0067 283:1<109 2011 283 404 https://doi.org/10.1007/s00404-010-1389-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1389-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hertlein Linda Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Lenhard Miriam Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Kirschenhofer Angela Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Kahlert Steffen Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Mayr Doris Department of Pathology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Munich, Germany aut NATIONALLICENCE 700 1- Burges Alexander Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Friese Klaus Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/1(2011-01-01), 109-113 0932-0067 283:1<109 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer