caa a22 4500 445306327 CHVBK 20180317142614.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00404-010-1385-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1385-5 Radiochemotherapy versus radiotherapy in locally advanced cervical cancer: a meta-analysis [Elektronische Daten] [Na Wang, Quan-Lin Guan, Kai Wang, Xin Zhou, Chen Gao, Han-Teng Yang, Tian-Gen Ni] Objective: The objectives of this review are to compare the effectiveness and safety of radiochemotherapy (RTCT) with radiotherapy (RT) alone in locally advanced cervical cancer (LACC). Data sources: We comprehensively searched the Cochrane library, Medline, EMBASE, Chinese biomedicine literature database, Chinese scientific full-text database and Chinese journal full-text database for relevant articles. The computer search was supplemented with a manual search of reference lists for all available review articles. Also reference lists of the included studies were reviewed. Results: We included 18 randomized trials involving 3,517 patients. Meta-analysis results are as follows: the response rate, 3 and 5-year survival rates were significantly better in patients in the RTCT group than in RT group. As adverse effects, limited evidence suggests that there was no significant difference between the two groups with regard to rectitis, cystitis, nausea and vomiting. But RTCT group has higher incidence rates than RT group in gastrointestinal, myelosuppression and leucopenia. Conclusion: The combination of radiotherapy and chemotherapy was more effective for LACC than radiotherapy alone. There was no significant difference between the RTCT regimen group and RT regimen group with regard to adverse effects. Springer-Verlag, 2010 Radiochemotherapy nationallicence Radiotherapy nationallicence Cervical cancer nationallicence Meta-analysis nationallicence Wang Na Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut Guan Quan-Lin Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut Wang Kai Department of Surgery of Second Hospital of Lanzhou University, Lanzhou, Gansu, China aut Zhou Xin Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut Gao Chen Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut Yang Han-Teng Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut Ni Tian-Gen Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut Archives of Gynecology and Obstetrics Springer-Verlag 283/1(2011-01-01), 103-108 0932-0067 283:1<103 2011 283 404 https://doi.org/10.1007/s00404-010-1385-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1385-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Na Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Guan Quan-Lin Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Wang Kai Department of Surgery of Second Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Zhou Xin Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Gao Chen Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Yang Han-Teng Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Ni Tian-Gen Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/1(2011-01-01), 103-108 0932-0067 283:1<103 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer