caa a22 4500 445306491 CHVBK 20180317142614.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00404-010-1653-4 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1653-4 Treatment of recurrent vulvar Paget disease with imiquimod cream: a case report and review of the literature [Elektronische Daten] [Esra Tonguc, Tayfun Güngor, Turgut Var, Mustafa Ozat, Izzet Sahin, Levent Sirvan] Introduction: Extra-mammary Paget disease is one of the rare neoplastic conditions of the skin. The most common site of involvement is the vulva and presents itself with erythematous plaques. Surgery is the most important treatment option. In the recent years, there are publications of the topical use of imiquimod cream in extra-mammary cutaneous Paget disease. We report the case of a woman with recurrent vulvar Paget disease, who underwent successful treatment with imiquimod cream. We also review the reports of other patients with vulvar Paget disease who were treated with topical imiquimod cream. Case report: A 65-year-old woman presented to the Oncology Outpatient Clinic with an itchy lesion in her vulva for 2years. In the gynecologic examination, a hyperkeratotic erythematous lesion was found starting from the right labium to involve clitoris, with a size of 4×3cm. Pathology result was reported as Paget disease. She was operated and wide vulvar excision was performed with a safety margin of 2cm. Then recurrence two times occurred. Because she refused surgery, imiquimod cream 5% was applied for treatment. Conclusion: Imiquimod cream is an effective and safe therapeutic agent for both primary and recurring vulvar Paget disease. Springer-Verlag, 2010 Vulva nationallicence Paget disease nationallicence Recurrence nationallicence Imiquimod cream nationallicence Treatment nationallicence Tonguc Esra Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut Güngor Tayfun Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut Var Turgut Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut Ozat Mustafa Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut Sahin Izzet Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut Sirvan Levent Department of Pathology, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/1(2011-01-01), 97-101 0932-0067 283:1<97 2011 283 404 https://doi.org/10.1007/s00404-010-1653-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1653-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tonguc Esra Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Güngor Tayfun Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Var Turgut Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Ozat Mustafa Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Sahin Izzet Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad.Binnaz Sok.No:1/5 Kavaklidere, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Sirvan Levent Department of Pathology, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/1(2011-01-01), 97-101 0932-0067 283:1<97 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer