caa a22 4500 445306556 CHVBK 20180317142614.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1550-x doi (NATIONALLICENCE)springer-10.1007/s00404-010-1550-x Is genetic polymorphism of ER-α, CYP1A1, and CYP1B1 a risk factor for uterine leiomyoma? [Elektronische Daten] [Gehan El-Shennawy, Abd-Alla Elbialy, Anwar Isamil, Manal El Behery] Introduction: Uterine leiomyoma is the most common benign smooth muscle tumor. Objective: This study was carried out to evaluate the association of ER-α, CYP1A1, and CYP1B1 polymorphisms with uterine leiomyoma in Egyptian women. Methods: The study population consisted of 160 patients with uterine leiomyoma and 100 healthy women as control. The genetic polymorphisms for ER-α MSP1 exon 1, CYP1B1 Leu432Val, and CYP1A1 Ile462Val were analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. Results: There were no statistically significant differences in the overall associations between the ER-α exon I CT genotypes and uterine leiomyoma (P=0.47). However, an elevated risk of uterine leiomyoma was observed among women with the CYP1A1 Ile462Val AG genotype (P=0.07) and CYP1B1 Leu 432Val C/C genotype (P=0.08). Conclusion: We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the susceptibility to leiomyoma in Egyptian women and they are likely to contribute in the pathogenesis of leiomyoma. Springer-Verlag, 2010 ER-α nationallicence CYP1A1 nationallicence Polymorphism nationallicence Uterine myoma nationallicence El-Shennawy Gehan Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut Elbialy Abd-Alla Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut Isamil Anwar Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut El Behery Manal Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1313-1318 0932-0067 283:6<1313 2011 283 404 https://doi.org/10.1007/s00404-010-1550-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1550-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- El-Shennawy Gehan Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 700 1- Elbialy Abd-Alla Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 700 1- Isamil Anwar Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 700 1- El Behery Manal Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1313-1318 0932-0067 283:6<1313 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer