caa a22 4500 445306564 CHVBK 20180317142614.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1584-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1584-0 Prevalence of human papillomavirus infection among women with and without normal cervical histology in Shandong Province, China [Elektronische Daten] [Xiaoyan Yuan, Yan Yang, Donghong Gu, Haining Liu, Haiqing Yang, Mingyi Wang] Objective: The purpose of this study was to investigate the prevalence of human papillomavirus (HPV) genotypes infection in women with and with normal cervical histology in the littoral region of Shandong, China. Methods: Scrape specimens were collected from 4,601 women for Pap smear and HPV genotypes identification. 1,489 women without normal cytology or with cervical disease were referred for colposcopic examination and biopsy procedures. Results: The HPV infection in healthy women of the littoral region of Shandong (9.61%) is lower than that observed in previous studies in China and much less than in the high-risk areas. HPV infection prevalence was 14.23% in cervicitis with normal cervical histology, which was significantly lower than that of the women without normal cervical histology (60.12%, P=0.00). Compared to prevalence of high-risk (HR) HPV genotypes (11.04%) in cervicitis with normal cervical histology, HR HPV genotypes prevalence (59.82%) was significantly higher in women without normal cervical histology (P=0.003). HPV types 16, 52, 58, and 31 were the most prevalent HPV genotypes found in women without normal cervical histology. No statistical difference was observed for multiple HR HPV genotypes infection between women with and without normal cervical histology (P=0.892). Conclusion: Compared with prevalence rates for other populations, the prevalence of specific-HPV genotypes infecting women is different in the littoral region of Shandong Province, China. Springer-Verlag, 2010 Human papillomavirus nationallicence Prevalence nationallicence Normal cervical histology nationallicence China nationallicence Yuan Xiaoyan Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut Yang Yan Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut Gu Donghong Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut Liu Haining Department of Obstetrics and Gynecology, Weihai Municipal Hospital, Dalian Medical University, Weihai, Shandong, China aut Yang Haiqing Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut Wang Mingyi Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1385-1389 0932-0067 283:6<1385 2011 283 404 https://doi.org/10.1007/s00404-010-1584-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1584-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yuan Xiaoyan Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut NATIONALLICENCE 700 1- Yang Yan Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut NATIONALLICENCE 700 1- Gu Donghong Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut NATIONALLICENCE 700 1- Liu Haining Department of Obstetrics and Gynecology, Weihai Municipal Hospital, Dalian Medical University, Weihai, Shandong, China aut NATIONALLICENCE 700 1- Yang Haiqing Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut NATIONALLICENCE 700 1- Wang Mingyi Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, 264200, Weihai, Shandong, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1385-1389 0932-0067 283:6<1385 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer