caa a22 4500 445306610 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1565-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1565-3 Cellular proliferation in female pelvic organ prolapse: a pilot study [Elektronische Daten] [Peter Takacs, Cristina Saiz, Sindy Jaramillo, Yanping Zhang, Sujata Yavagal, Keith Candiotti, Carlos Medina] Purpose: To assess cell proliferation in pelvic organ prolapse (POP). Methods: Tissue samples of the anterior vaginal wall and uterosacral ligaments (USLs) were obtained from eight women with combined anterior vaginal wall and uterine prolapse and from eight women without POP in a standardized fashion. Immunohistochemistry against Ki-67 was used to assess cell proliferation in vaginal and USL biopsies. Results: There were no significant differences in age, parity, menopausal status or hormone replacement therapy between the two groups. The POP-Q stage of uterine and anterior vaginal wall prolapse was significantly higher in the group of women with prolapse compared to the group without prolapse [median (range) 3 (3-4) vs. 0 (0), <0.01]. There was no significant difference between Ki-67 expressions in women with or without prolapse. Conclusion: There were no significant differences in cell proliferation between samples from women with or without POP. Springer-Verlag, 2010 Prolapse nationallicence Cystocele nationallicence Smooth muscle nationallicence Cell proliferation nationallicence Takacs Peter Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut Saiz Cristina Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut Jaramillo Sindy Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut Zhang Yanping Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, USA aut Yavagal Sujata Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut Candiotti Keith Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, USA aut Medina Carlos Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1329-1332 0932-0067 283:6<1329 2011 283 404 https://doi.org/10.1007/s00404-010-1565-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1565-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takacs Peter Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut NATIONALLICENCE 700 1- Saiz Cristina Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut NATIONALLICENCE 700 1- Jaramillo Sindy Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut NATIONALLICENCE 700 1- Zhang Yanping Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, USA aut NATIONALLICENCE 700 1- Yavagal Sujata Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut NATIONALLICENCE 700 1- Candiotti Keith Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, USA aut NATIONALLICENCE 700 1- Medina Carlos Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, P.O. Box 016960, 33010, Miami, FL, USA aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1329-1332 0932-0067 283:6<1329 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer