caa a22 4500 445306653 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1581-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1581-3 Preceding cervical cytology in women with high-grade squamous intraepithelial lesion [Elektronische Daten] [Sorramon Songveeratham, Chumnan Kietpeerakool, Surapan Khunamornpong, Narisa Sribanditmongkol, Jatupol Srisomboon] Objective: To evaluate the preceding cervical cytology and factors leading to cytohistologic discrepancy in women with high-grade squamous intraepithelial lesion (HSIL) histology. Methods: The records of women who were found to have histologically confirmed HSIL without any associated invasive and glandular lesions, at Chiang Mai University Hospital between January 2005 and May 2009, were reviewed. Cytohistological discrepancy was defined as HSIL histology preceded by low-grade squamous intraepithelial lesion (LSIL) and atypical squamous cells of undetermined significance (ASC-US) smears. Results: The records of 436 HSIL cases were reviewed. The mean age of the women was 45.0±9.3years. The preceding smear abnormalities were as follows: 275 (63.1%) with HSIL; 50 (11.5%) with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H); 40 (9.2%) with squamous cell carcinoma; 35 (8.0%) with LSIL; 32 (7.3%) with ASC-US; and 4 (0.9) with glandular abnormality smears. Overall, the rate of cytohistological discrepancy was 15.4% (95% CI 12.1-19.1%). The small size of HSIL and presence of coexisting LSIL are significant independent predictors for cytohistologic discrepancy. Conclusion: Approximately 15% of HSIL cases are under-diagnosed by cytology. Significant factors leading to cytohistologic discrepancy are lesion size and the presence of coexisting LSIL. Springer-Verlag, 2010 High-grade squamous intraepithelial lesion nationallicence Cervical cytology nationallicence Pap smear nationallicence Discrepancy nationallicence Songveeratham Sorramon Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut Kietpeerakool Chumnan Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut Khunamornpong Surapan Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand aut Sribanditmongkol Narisa Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut Srisomboon Jatupol Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1381-1384 0932-0067 283:6<1381 2011 283 404 https://doi.org/10.1007/s00404-010-1581-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1581-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Songveeratham Sorramon Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut NATIONALLICENCE 700 1- Kietpeerakool Chumnan Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut NATIONALLICENCE 700 1- Khunamornpong Surapan Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand aut NATIONALLICENCE 700 1- Sribanditmongkol Narisa Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut NATIONALLICENCE 700 1- Srisomboon Jatupol Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1381-1384 0932-0067 283:6<1381 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer