caa a22 4500 445306718 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-011-1889-7 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1889-7 Anti-Mullerian hormone is a better marker than inhibin B, follicle stimulating hormone, estradiol or antral follicle count in predicting the outcome of in vitro fertilization [Elektronische Daten] [Cigdem Kunt, Gulnur Ozaksit, Raziye Keskin Kurt, Ayse Cakir Gungor, Mine Kanat-Pektas, Sevtap Kilic, Arzu Dede] Objective: The present study aims to compare anti-Mullerian hormone (AMH) with other ovarian reserve markers and to find a cut-off value of AMH for predicting ovarian response towards controlled ovarian hyperstimulation in an in vitro fertilization (IVF) program. Materials and methods: A prospective analysis was performed in 180 patients undergoing their first IVF trial, which is being conducted at a department of assisted reproduction in a tertiary medical center. The main outcome measures were determined as age and antral follicle count as well as the serum concentrations of follicle stimulating hormone, luteinizing hormone (LH), estradiol (E2), inhibin B and AMH. The predictive power of the aforementioned measures in specifying ovarian response was determined by means of discriminate analyses. Results: As expected, day 3 LH levels were significantly high in the poor responder group. The poor responders had significantly lower antral follicle counts, retrieved oocyte number, and mature oocyte counts as well as day 3 AMH levels (5.8±2.32 vs. 1.8±0.80ng/ml). There was a positive correlation with antral follicle count, basal AMH, E2 and follicle count on the day of HCG administration and negative correlation with age. The AMH level was addressed as the only significant factor in determination of mature oocyte number. A cut-off point for serum AMH concentration indicating the value of 2.97ng/ml was found to predict the poor ovarian response with a sensitivity of 100.0% and a specificity of 89.6%. However, the same cut-off point was not as predictive for the non-conception circumstance. Conclusion: The present study concludes that AMH is a promising biochemical marker for the prediction of ovarian response and that a cut-off point indicating the value of 2.97ng/ml can be adopted for this prediction. Springer-Verlag, 2011 Anti-Mullerian hormone nationallicence In vitro fertilization nationallicence Ovarian reserve nationallicence Poor ovarian response nationallicence Kunt Cigdem Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Ozaksit Gulnur Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Keskin Kurt Raziye Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Cakir Gungor Ayse Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Kanat-Pektas Mine Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Kilic Sevtap Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Dede Arzu Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1415-1421 0932-0067 283:6<1415 2011 283 404 https://doi.org/10.1007/s00404-011-1889-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1889-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kunt Cigdem Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 700 1- Ozaksit Gulnur Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 700 1- Keskin Kurt Raziye Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 700 1- Cakir Gungor Ayse Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 700 1- Kanat-Pektas Mine Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 700 1- Kilic Sevtap Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 700 1- Dede Arzu Department of Assisted Reproduction Technology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1415-1421 0932-0067 283:6<1415 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer