caa a22 4500 445306793 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1506-1 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1506-1 Obstetrical and fetal outcomes of a new management strategy in patients with intra-hepatic cholestasis of pregnancy [Elektronische Daten] [Hani Al Shobaili, Hossam Hamed, Ahmad Al Robaee, Abdullateef Alzolibani, Ahmad Amin, Salah Ahmad] Purposes: To determine the incidence, obstetrical, and fetal complication rates of intrahepatic cholestasis of pregnancy (ICP) in patients managed expectantly to 40-weeks gestation. Methods: In a prospective cohort study conducted between February 2008 and January 2010, a total of 21,960 pregnant women in Qassim Region of Saudi Arabia were screened for ICP using specific criteria for diagnosis. The course of pregnancy was monitored to 40-weeks gestation or spontaneous onset of labor, whichever comes first. The measured outcomes were compared with a cross-matched group of healthy pregnant women. Continuous variables were analyzed with t test, while χ2 test was used for comparing percentages. Results: The incidence of ICP was 0.35% (76/21,960). There was no significant difference between groups in gestational age at delivery, preterm labor, intrauterine fetal death, cesarean section, or respiratory distress syndrome. There was significantly higher intrapartum non-reassuring fetal heart rate patterns and meconium-stained amniotic fluid in ICP group (P<0.01 and <0.0001, respectively). Conclusions: The incidence of ICP in this region is low compared to worldwide range. Expectant management to 40-weeks gestation is associated with obstetrical and fetal outcomes comparable to normal pregnancy; however, intrapartum fetal asphyxia is more likely. Springer-Verlag, 2010 Pregnancy nationallicence Pruritus nationallicence Intrahepatic cholestasis nationallicence Obstetrical outcome nationallicence Al Shobaili Hani Department of Dermatology, Qassim University, Qassim, Saudi Arabia aut Hamed Hossam Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Qassim, Saudi Arabia aut Al Robaee Ahmad Department of Dermatology, Qassim University, Qassim, Saudi Arabia aut Alzolibani Abdullateef Department of Dermatology, Qassim University, Qassim, Saudi Arabia aut Amin Ahmad Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Qassim, Saudi Arabia aut Ahmad Salah Department of Obstetrics and Gynecology, Maternity-Childhood Hospital, Qassim, Qassim Region, Saudi Arabia aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1219-1225 0932-0067 283:6<1219 2011 283 404 https://doi.org/10.1007/s00404-010-1506-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1506-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Al Shobaili Hani Department of Dermatology, Qassim University, Qassim, Saudi Arabia aut NATIONALLICENCE 700 1- Hamed Hossam Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Qassim, Saudi Arabia aut NATIONALLICENCE 700 1- Al Robaee Ahmad Department of Dermatology, Qassim University, Qassim, Saudi Arabia aut NATIONALLICENCE 700 1- Alzolibani Abdullateef Department of Dermatology, Qassim University, Qassim, Saudi Arabia aut NATIONALLICENCE 700 1- Amin Ahmad Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Qassim, Saudi Arabia aut NATIONALLICENCE 700 1- Ahmad Salah Department of Obstetrics and Gynecology, Maternity-Childhood Hospital, Qassim, Qassim Region, Saudi Arabia aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1219-1225 0932-0067 283:6<1219 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer