caa a22 4500 445306815 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-011-1881-2 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1881-2 Simultaneous administration of mifepristone and misoprostol for early termination of pregnancy: a randomized controlled trial [Elektronische Daten] [Anupama Goel, Sandhya Mittal, B. Taneja, Neerja Singal, Shivani Attri] Aim: To compare the efficacy of different intervals of misoprostol administration (simultaneously vis-à-vis 24h), after mifepristone, in women undergoing medical termination of pregnancy up to gestation of 49days. Methods: Eighty eligible women with single intrauterine pregnancy of ≤7weeks of gestation requesting abortion were randomized to receive either 200mg of mifepristone orally and 400μg of misoprostol vaginally simultaneously (Group 1) or at 24-h interval (Group 2).Women who had no bleeding after the drugs were offered a second dose of misoprostol 24h after the first dose. All patients were followed up on day 14. Primary outcome measure was the complete abortion rate. Secondary outcome measures were the induction-abortion interval, adverse effects, especially bleeding, and treatment acceptability rate. Treatment was considered a failure if surgical intervention was needed for any indication. Results: Complete abortion was achieved in 38 women [95%; 95% confidence interval (CI) 88%, 100%] in Group 1 and 39 women (97.50%; 95% CI 93%,100%) in Group 2 (p=0.56). A second dose of misoprostol was needed in two patients in Group 1 and in only one patient in Group 2. The induction-abortion interval was 6.50±1.48h in Group 1 and 5.95±1.81h in Group 2 (p=0.13). The difference in frequency of adverse effects in the two groups was statistically insignificant (p=0.18). The treatment acceptability rate was 97.50% in Group 1 and 95% in Group 2 (p=0.56). Conclusion: Simultaneous administration of mifepristone and 400μg vaginal misoprostol is an effective alternative to standard regimens for medical abortion up to 49days of gestation. Springer-Verlag, 2011 Medical abortion nationallicence Mifepristone nationallicence Misoprostol nationallicence Pregnancy termination nationallicence Goel Anupama Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut Mittal Sandhya Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut Taneja B. Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut Singal Neerja Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut Attri Shivani Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1409-1413 0932-0067 283:6<1409 2011 283 404 https://doi.org/10.1007/s00404-011-1881-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1881-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goel Anupama Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut NATIONALLICENCE 700 1- Mittal Sandhya Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut NATIONALLICENCE 700 1- Taneja B. Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut NATIONALLICENCE 700 1- Singal Neerja Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut NATIONALLICENCE 700 1- Attri Shivani Obstetrics and Gynaecology Department, MMIMSR, Mullana (Ambala), Haryana, India aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1409-1413 0932-0067 283:6<1409 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer