caa a22 4500 44530684X CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1535-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1535-9 Comparison of isosorbide mononitrate and misoprostol for cervical ripening in termination of pregnancy between 8 and 12weeks: a randomized controlled trial [Elektronische Daten] [Nirmala Duhan, Sonam Gupta, Krishna Dahiya, Daya Sirohiwal, Seema Rohilla] Aim: The present study was undertaken to compare the efficacy of isosorbide mononitrate (IMN) and misoprostol for cervical ripening in termination of pregnancy between 8 and 12weeks. Materials and methods: This prospective randomized single blind study enrolled 40 women with singleton pregnancy seeking surgical termination of pregnancy between 8 and 12weeks of gestation. They were divided into two groups—group I received IMN 40mg while group II received misoprostol 40mg vaginally, 3h prior to suction and evacuation. All women were monitored for effects of cervical ripening and adverse effects. Results: The mean sizes of dilators that could be negotiated without any resistance was 5.9±1.33 in group I and 8.6±0.94 in group II (p<0.001, 95% CI 0.58, 0.41). The mean dilator sizes at which resistance was first encountered was 6.9±1.37 in group I and 9.9±1.23 in group II (p<0.001, 95% CI 0.60, 0.54). The mean blood loss was 61.5±13.86ml in group I and 36.25±12.80ml in group II (p<0.001, 95% CI 6.07, 5.63). Headache was the most common adverse effect seen with IMN use. Conclusion: The results show that IMN has a definite role and better safety profile than misoprostol in first trimester cervical ripening, although misoprostol is more effective and causes less blood loss. Springer-Verlag, 2010 Isosorbide mononitrate nationallicence Misoprostol nationallicence Cervical ripening nationallicence Early pregnancy nationallicence Duhan Nirmala Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut Gupta Sonam Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut Dahiya Krishna Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut Sirohiwal Daya Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut Rohilla Seema Department of Radiodiagnosis, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1245-1248 0932-0067 283:6<1245 2011 283 404 https://doi.org/10.1007/s00404-010-1535-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1535-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duhan Nirmala Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut NATIONALLICENCE 700 1- Gupta Sonam Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut NATIONALLICENCE 700 1- Dahiya Krishna Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut NATIONALLICENCE 700 1- Sirohiwal Daya Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, 124001, Rohtak, Haryana, India aut NATIONALLICENCE 700 1- Rohilla Seema Department of Radiodiagnosis, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1245-1248 0932-0067 283:6<1245 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer