caa a22 4500 445306858 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1543-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1543-9 Etanercept causes regression of endometriotic implants in a rat model [Elektronische Daten] [Gazi Yildirim, Rukset Attar, Cem Ficicioglu, Ates Karateke, Ferda Ozkan, Narter Yesildaglar] Objective: To determine the effects of etanercept (anti-TNF-α) on surgically induced endometriosis in a rat model. Materials and methods: This is a prospective, randomized, controlled, experimental study that was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Thirty female nonpregnant, nulligravid Wistar-Hannover albino rats were used. The summary of the technique: surgical induction of endometriosis, administration of estrogen for 2weeks, and laparotomy; administration of etanercept for 2weeks following the induction of endometriosis and laparotomy; administration of estrogen for 2weeks and necropsy. The volume and histopathological scores of the endometriotic foci were evaluated. Results: One-hundred twenty uterine horns were implanted in 30 rats. Endometriosis was completely formatted in 112 lesions (93.3%). No rats were lost. In the etanercept group, the lesions' volumes were 83.9±13.1, 47.2±8.4, and 96.7±34.8mm3 at the end of the second week (pretreatment stage), at the end of the fourth week (post-treatment stage), and at the end of the sixth week, respectively (P=0.007). Histopathologic scores were 2.3±0.2, 1.7±0.2, and 1.9±0.1, respectively (P=0.08). The changes in the other groups were not statistically significant. Conclusions: Etanercept, a fusion protein consisting of human recombinant soluble TNF receptor-2, neutralizes TNF activity. Anti-TNF therapy could be a new non-hormonal therapeutic option for the treatment of endometriosis in humans. Springer-Verlag, 2010 Endometriosis nationallicence Etanercept nationallicence Anti-TNF nationallicence Rat endometriosis model nationallicence Yildirim Gazi Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut Attar Rukset Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut Ficicioglu Cem Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut Karateke Ates Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut Ozkan Ferda Department of Pathology, Yeditepe University Hospital, Istanbul, Turkey aut Yesildaglar Narter Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1297-1302 0932-0067 283:6<1297 2011 283 404 https://doi.org/10.1007/s00404-010-1543-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1543-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yildirim Gazi Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut NATIONALLICENCE 700 1- Attar Rukset Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ficicioglu Cem Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut NATIONALLICENCE 700 1- Karateke Ates Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ozkan Ferda Department of Pathology, Yeditepe University Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yesildaglar Narter Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Yeditepe University Hospital, Devlet Yolu, Ankara Cad. No:102-104, Kozyatagi, 34752, Istanbul, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1297-1302 0932-0067 283:6<1297 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer