caa a22 4500 445306866 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1569-z doi (NATIONALLICENCE)springer-10.1007/s00404-010-1569-z Hussein Mostafa Obstetrics and Gynecology Department, Woman's Health Center, Assiut University Hospitals, Assiut, Egypt aut Transvaginal Doppler sonography for evaluation of irregular uterine bleeding with DMPA [Elektronische Daten] [Mostafa Hussein] Background: The main cause for discontinuation of depot medroxyprogesterone acetate (DMPA) use is irregular menstrual bleeding. The exact pathophysiological mechanisms of irregular bleeding have remained unclear. Transvaginal Doppler is a non-invasive method for studying changes in blood flow which may highlight the underlying pathology in those cases with irregular uterine bleeding. The aim of this study was to quantify the uterine and subendometrial microvasculature in DMPA users with irregular bleeding pattern in comparison to DMPA users with amenorrhea. Study design: This is a case control study. Forty users of DMPA were divided into two groups: one group included 20 users with irregular uterine bleeding and the second group included 20 amenorrheic users. Pulsatility index (PI) and resistance index (RI) of uterine and subendometrial blood vessels were determined. Power Doppler Energy was used to quantify the signal percentage of the subendometrial area. Results: There is significant reduction of PI and RI in the uterine artery and subendometrial microvasculature in cases of irregular uterine bleeding. Conclusion: Irregular uterine bleeding with DMPA associated with increased perfusion of uterine and subendometrial blood vessels. Springer-Verlag, 2010 DMPA nationallicence PI nationallicence RI nationallicence Subendometrial Doppler nationallicence Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1325-1328 0932-0067 283:6<1325 2011 283 404 https://doi.org/10.1007/s00404-010-1569-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1569-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hussein Mostafa Obstetrics and Gynecology Department, Woman's Health Center, Assiut University Hospitals, Assiut, Egypt aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1325-1328 0932-0067 283:6<1325 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer