caa a22 4500 445306874 CHVBK 20180317142615.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-010-1545-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1545-7 The effect of vaginally administered genistein in comparison with hyaluronic acid on atrophic epithelium in postmenopause [Elektronische Daten] [Maria Le Donne, Carmela Caruso, Alfredo Mancuso, Gregorio Costa, Raffaella Iemmo, Giovanni Pizzimenti, Vittorio Cavallari] Purpose: The quality of life in postmenopause is seriously affected by the symptoms related to vaginal atrophy. To evaluate in a 3-month, prospective, randomized, double blind, study whether vaginal suppositories containing genistein might improve genital symptoms, colposcopical and cytologic findings or modify DNA cytometric features in postmenopausal women affected by vaginal atrophy, in comparison with vaginal suppositories containing hyaluronic acid (HA). Methods: A total of 62 postmenopausal women were randomly assigned to receive intravaginally 97μg of genistein (group A, n=31) or 5mg of HA (group B, n=31) daily for 15days continuously/month for 3months. Vaginal and cervical smear, colposcopy, vaginal biopsy were performed before and at the end of the study. Maturation value (MV) was calculated. Flow cytometric analysis of DNA ploidy (DI) and S-phase fraction (SPF) were performed. Results: After 90days of study, a significant improvement was obtained in genital symptoms, colposcopy scores and MV (p<0.001) in both groups; the improvement obtained by genistein was more effective especially regarding genital score (p value between groups 0.001). No significant change was found in SPF value and DI. Conclusion: Both treatments improved genital symptoms, colposcopical features and MV, although genistein was more effective on genital score. Both treatments did not significantly influence flow cytometry parameters, although genistein showed slight decrease in DI, with a normalization of the aneuploid content present in some cases that could represent an additional application of intravaginal phytoestrogen therapy, providing an alternative therapy of vaginal atrophy in postmenopausal patients. The results of this investigation should be considered preliminary and need to be verified in larger, prospective studies. Springer-Verlag, 2010 Menopause nationallicence Genistein nationallicence Hyaluronic acid nationallicence Vaginal atrophy nationallicence S-phase fraction nationallicence DNA ploidy nationallicence Le Donne Maria Department of Gynecological, Obstetric Sciences and Reproductive Medicine, University of Messina, Azienda Ospedaliera Universitaria "G. Martino”, Via Consolare Valeria, 98125, Messina, Italy aut Caruso Carmela Department of Gynecological, Obstetric Sciences and Reproductive Medicine, University of Messina, Azienda Ospedaliera Universitaria "G. Martino”, Via Consolare Valeria, 98125, Messina, Italy aut Mancuso Alfredo Department of Gynecological, Obstetric Sciences and Reproductive Medicine, University of Messina, Azienda Ospedaliera Universitaria "G. Martino”, Via Consolare Valeria, 98125, Messina, Italy aut Costa Gregorio Department of Human Pathology, University of Messina, Messina, Italy aut Iemmo Raffaella Department of Human Pathology, University of Messina, Messina, Italy aut Pizzimenti Giovanni Department of Physics-Informatics Unit, University of Messina, Messina, Italy aut Cavallari Vittorio Department of Human Pathology, University of Messina, Messina, Italy aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1319-1323 0932-0067 283:6<1319 2011 283 404 https://doi.org/10.1007/s00404-010-1545-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1545-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Le Donne Maria Department of Gynecological, Obstetric Sciences and Reproductive Medicine, University of Messina, Azienda Ospedaliera Universitaria "G. Martino”, Via Consolare Valeria, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Caruso Carmela Department of Gynecological, Obstetric Sciences and Reproductive Medicine, University of Messina, Azienda Ospedaliera Universitaria "G. Martino”, Via Consolare Valeria, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Mancuso Alfredo Department of Gynecological, Obstetric Sciences and Reproductive Medicine, University of Messina, Azienda Ospedaliera Universitaria "G. Martino”, Via Consolare Valeria, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Costa Gregorio Department of Human Pathology, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Iemmo Raffaella Department of Human Pathology, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Pizzimenti Giovanni Department of Physics-Informatics Unit, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Cavallari Vittorio Department of Human Pathology, University of Messina, Messina, Italy aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1319-1323 0932-0067 283:6<1319 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer