caa a22 4500 445306882 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00404-011-1845-6 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1845-6 Malignant mixed Mullerian tumor of the ovary with two cases and review of the literature [Elektronische Daten] [Berna Duman, Ismail Kara, Meral Günaldi, Vehbi Ercolak] Introduction: Malignant mixed Müllerian tumor (MMMT) of the ovary is a rare and highly aggressive tumor. It accounts <1% of all ovarian carcinomas. It is characterized by the presence of both carcinomatous and sarcomatous components and tends to occur in low parity postmenopausal woman. These are mixed, mostly monoclonal tumors, and the predominance of the stromal component aggravates the prognosis. The staging system for ovarian and primary peritoneal cancer is also used for MMMT. After complete surgical staging, patient with stage II-IV at the time of surgery should have postoperative chemotherapy. Chemotherapy can be considered for stage I MMMT. Its optimal treatment is debatable. Taxane and platinum combination is standard for the epithelial ovarian carcinoma. There is very limited literature reporting this combination therapy in ovarian MMMTs. Case 1 and Case 2: We presented two cases of stage III primary ovarian MMMT. The patients were treated with the taxane/platin combination, without adverse events following surgery, and remained in clinical remission in Case 1 at follow-up. Case 2 has progressed after first line taxane/platin regimen and treated like epithelial ovarian carcinoma. Case 1 was in complete remission in the follow-up visit 2years later. Case 2 died 14months later after the tumor was initially diagnosed. Conclusion: Predominating carcinomatous or sarcomatous component should be taken into consideration in predicting the response and planning the chemotherapy protocol. Springer-Verlag, 2011 Mixed müllerian nationallicence Ovarian neoplasms nationallicence Chemotherapy nationallicence Duman Berna Department of Oncology, Çukurova University Hospital, Adana, Turkey aut Kara Ismail Department of Oncology, Çukurova University Hospital, Adana, Turkey aut Günaldi Meral Department of Oncology, Çukurova University Hospital, Adana, Turkey aut Ercolak Vehbi Department of Oncology, Çukurova University Hospital, Adana, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1363-1368 0932-0067 283:6<1363 2011 283 404 https://doi.org/10.1007/s00404-011-1845-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1845-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duman Berna Department of Oncology, Çukurova University Hospital, Adana, Turkey aut NATIONALLICENCE 700 1- Kara Ismail Department of Oncology, Çukurova University Hospital, Adana, Turkey aut NATIONALLICENCE 700 1- Günaldi Meral Department of Oncology, Çukurova University Hospital, Adana, Turkey aut NATIONALLICENCE 700 1- Ercolak Vehbi Department of Oncology, Çukurova University Hospital, Adana, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/6(2011-06-01), 1363-1368 0932-0067 283:6<1363 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer