caa a22 4500 44530698X CHVBK 20180627064139.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1772-y doi (NATIONALLICENCE)springer-10.1007/s00404-010-1772-y Fertility preservation in >1,000 patients: patient's characteristics, spectrum, efficacy and risks of applied preservation techniques [Elektronische Daten] [Barbara Lawrenz, Julia Jauckus, Markus Kupka, Thomas Strowitzki, Michael von Wolff] Introduction: Data on the characteristics of female patients counselled for fertility preservation and the efficacy and risk of the applied procedures are still poor. We therefore analysed the registry of a network of 70 infertility centers which are involved in fertility preservation in Germany, Switzerland and Austria, called FertiPROTEKT (hhtp://www.fertiprotekt.eu). Materials and methods: 1,280 counselled patients (15-40years) were analysed regarding characteristics and different fertility preservation treatments before cytotoxic therapy in 2007-2009. Results: 34.8% of the counselled patients were diagnosed with breast cancer, 30.5% with Hodgkin's lymphoma, 25.4% with other malignancies and 9.3% with non-malignant diseases. 89.6% of the treated breast cancer patients were 25-40years of age, and 87.5% of the lymphoma patients were 15-30years of age. At the time of counselling, 85.3% of the breast cancer patients and 92.7% of the lymphoma patients were childless. 1,080 patients received a single or combined therapy such as GnRH agonists (n=823), cryopreservation of ovarian tissue (n=500), ovarian stimulation (n=221) and transposition of the ovaries (n=24). Only one severe complication, requiring postponement of the chemotherapy, was documented. In stimulated patients, 2,417 oocytes (mean n=11.6, SD±7.7) were received. Fertilisation rate per received oocyte was 61.3%. Conclusions: Fertility preservation programmes mainly involve women without children, diagnosed with breast cancer or Hodgkin's lymphoma. Fertility preservation techniques can be applied with low risk. The limited and age-dependant success rate of the different therapies require individualised approaches of single or combined fertility preservation techniques. Springer-Verlag, 2010 Fertility preservation nationallicence IVF nationallicence Cancer nationallicence Oocyte nationallicence GnRH nationallicence Cryopreservation nationallicence Lawrenz Barbara University Women's Hospital, Tübingen, Germany aut Jauckus Julia Department of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Heidelberg, Germany aut Kupka Markus University Women's Hospital, Klinikum Maistrasse, Munich, Germany aut Strowitzki Thomas Department of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Heidelberg, Germany aut von Wolff Michael Department of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Effingerstrasse 102, 3010, Bern, Switzerland aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 651-656 0932-0067 283:3<651 2011 283 404 https://doi.org/10.1007/s00404-010-1772-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1772-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lawrenz Barbara University Women's Hospital, Tübingen, Germany aut NATIONALLICENCE 700 1- Jauckus Julia Department of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Heidelberg, Germany aut NATIONALLICENCE 700 1- Kupka Markus University Women's Hospital, Klinikum Maistrasse, Munich, Germany aut NATIONALLICENCE 700 1- Strowitzki Thomas Department of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Heidelberg, Germany aut NATIONALLICENCE 700 1- von Wolff Michael Department of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Effingerstrasse 102, 3010, Bern, Switzerland aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 651-656 0932-0067 283:3<651 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 44530698X BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer