caa a22 4500 445306998 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1395-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1395-3 Adverse pregnancy outcomes and long-term morbidity after early fetal hypokinesia in maternal smoking pregnancies [Elektronische Daten] [Dubravko Habek, Melita Kovačević] Aim: The aim of this study is to evaluate perinatal outcome and subsequent morbidity and neurodevelopment in 10-year-old children with fetal hypokinesia intrauterinely verified by ultrasonography in early pregnancy as a pattern of abnormal fetal behavior due to maternal chronic smoking. This study revealed significant global fetal hypokinesia as well as head and arm hypokinesia in early pregnancy in mothers' chronic smokers (group 3—more than 20 cigarettes a day). Materials and methods: This retrospective study was performed in mothers and their 10-year-old children included in the study of the effect of cigarette smoking on fetal movements in early pregnancy. Perinatal outcome was assessed according to maternal data, course, and outcome of pregnancy and delivery. Data on the long-term (10years) development and morbidity from infancy during childhood until age 10years were obtained from the children's medical histories and medical rehabilitation records, maternal, and paternal histories. The psycholinguistic development was estimated. Results: In group 3, there was a poor overall perinatal outcome and high rate of the bronchoconstrictive syndrome and recurrent infections, while one case of the sudden infant death syndrome. Poor school performance was recorded in five children, attention-deficit/hyperactivity disorder in four, and autism, dystonia syndrome, social maladaptation, and minimally cerebral disfunction in one child each. Retarded psycholinguistic development was found in seven children, only three of them attending speech therapy (P<0.05). Conclusion: Fetal hypokinesia in early pregnancy related with maternal smoking was found to correlate with poor perinatal outcome, subsequent morbidity, and developmental impairments in 10-year-old children born to mothers smoking more than 20 cigarettes a day. Springer-Verlag, 2010 Smoking nationallicence Pregnancy nationallicence Perinatal outcome nationallicence Long-term sequels nationallicence Habek Dubravko Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Sveti Duh Hospital, Sveti Duh 64, 10000, Zagreb, Croatia aut Kovačević Melita Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Sveti Duh Hospital, Sveti Duh 64, 10000, Zagreb, Croatia aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 491-495 0932-0067 283:3<491 2011 283 404 https://doi.org/10.1007/s00404-010-1395-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1395-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Habek Dubravko Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Sveti Duh Hospital, Sveti Duh 64, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Kovačević Melita Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Sveti Duh Hospital, Sveti Duh 64, 10000, Zagreb, Croatia aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 491-495 0932-0067 283:3<491 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer