caa a22 4500 445307021 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1468-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1468-3 Pretreatment study of P53 overexpression for selection of candidates for pelvic lymphadenectomy in clinical stage I endometrial carcinoma: a randomized-controlled study [Elektronische Daten] [E. Fayallah, Reda Hemida, A. Gamal, E. Abd Elhady, K. Anwar, N. Nada, L. Sherif, M. Sayed-Ahmed] Purpose: To study the value of pretreatment testing of P53 overexpression in selection of candidates for pelvic lymphadenectomy in clinical stage I endometrial carcinoma. Patients and methods: This prospective randomized clinical study included 38 patients with histologically confirmed endometrial carcinoma and staged clinically as stage I. Immunohistochemical staining of the tumor specimens obtained by dilatation and curettage with P53 monoclonal antibodies was done. The patients were randomized into two groups according to the planned surgical treatment: hysterectomy group and hysterectomy plus pelvic lymphadenectomy group. Results: There was no significant difference in mean age, parity, medical status, surgical stage, histologic types, grade of differentiation, and myometrial invasion between the two groups. The survival rate in the hysterectomy group in our study was 82.4% and the recurrence rate was 17.6%, while in hysterectomy and lymphadenectomy group the survival rate was 81.0% and the recurrence rate was 19%. Adding pelvic lymphadenectomy was found to be associated with prolonged recurrence time in the P53-positive patients (24.07 vs. 17.8months for group A). Conclusion: Pretreatment testing of P53 expression is recommended to help with other prognostic factors in the selection of candidates for pelvic lymphadenectomy in clinical stage I endometrial carcinoma. Springer-Verlag, 2010 Endometrial carcinoma nationallicence Lymphadenectomy nationallicence P53 nationallicence Fayallah E. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut Hemida Reda Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut Gamal A. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut Abd Elhady E. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut Anwar K. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut Nada N. Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt aut Sherif L. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut Sayed-Ahmed M. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 617-622 0932-0067 283:3<617 2011 283 404 https://doi.org/10.1007/s00404-010-1468-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1468-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fayallah E. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut NATIONALLICENCE 700 1- Hemida Reda Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut NATIONALLICENCE 700 1- Gamal A. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut NATIONALLICENCE 700 1- Abd Elhady E. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut NATIONALLICENCE 700 1- Anwar K. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut NATIONALLICENCE 700 1- Nada N. Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Sherif L. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut NATIONALLICENCE 700 1- Sayed-Ahmed M. Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Elgomhoria street, Mansoura, Egypt aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 617-622 0932-0067 283:3<617 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer