caa a22 4500 44530703X CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1746-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1746-0 Focus on haematogenous dissemination of the malignant cystosarcoma phylloides: institutional experience [Elektronische Daten] [Lukas Schwentner, Christian Kurzeder, Rolf Kreienberg, Achim Wöckel] Introduction: Cystosarcoma phylloides (CSP) is a fibro-epithelial neoplasm of the breast. Not all CSP cases present as malignant tumors; they are therefore classified as benign, malignant, and borderline subtypes according to the WHO classification. The classification is based on several histopathological features of the neoplasm, such as mitosis rate or invasive growth of the tumor. The progression of this disease is mainly influenced by the classification of their degree. In western countries, this tumor entity usually occurs between 50 and 60years of age. The major problem in the handling of these patients is the high local recurrence rate, whereas haematogenous metastasis is seldom seen. We therefore report three cases of haematogenous spread in a group of eight patients (two borderline and six malignant cases of CSP). Materials and methods: In this study, we investigated all patients suffering from malignant or borderline CSP, between May 1995 and January 2009, who were under the care of the Department of Gynecology and Obstetrics, University Hospital, Ulm. A written and informed consent was obtained from all patients included in this retrospective study. During this period, eight patients, fulfilling the criteria discussed before, were under the care of the Department of Gynecology and Obstetrics. All therapeutic decisions were taken by the interdisciplinary tumor board of the department (after 1999). Results: In the retrospective analysis of our study group, we found a high percentage of haematogenous metastasis that was always accompanied with a very poor prognosis in malignant CSP patients. Those patients always died within a short period of time. Two of these patients showed, while they underwent initial surgery, no metastatic suspect lesions and underwent R0 resection; both received a radical mastectomy. One patient already showed lung metastasis while undergoing first line surgery, because she initially declined surgery. We therefore speculate that postoperative adjuvant chemotherapy could lead to a favorable outcome in high risk patients, concerning the development of haematogenous metastasis. Springer-Verlag, 2010 Cystosarcoma phylloides nationallicence Metastasis nationallicence Haematogenous metastasis nationallicence Schwentner Lukas Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut Kurzeder Christian Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut Kreienberg Rolf Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut Wöckel Achim Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 591-596 0932-0067 283:3<591 2011 283 404 https://doi.org/10.1007/s00404-010-1746-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1746-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schwentner Lukas Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Kurzeder Christian Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Kreienberg Rolf Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Wöckel Achim Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstraße 43, 89075, Ulm, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 591-596 0932-0067 283:3<591 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer