caa a22 4500 445307056 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1464-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1464-7 Expression of p16 protein and epidermal growth factor receptor in patients with adenocarcinoma of the uterine cervix: an immunohistochemical analysis [Elektronische Daten] [Klaus Bodner, Peter Laubichler, Oliver Kimberger, Klaus Czerwenka, Robert Zeillinger, Barbara Bodner-Adler] Objective: The present study assessed the expression of p16 and epidermal growth factor receptor (EGFR) in patients with adenocarcinoma of the uterine cervix to determine their influence on prognosis and to evaluate a possible association between their expression and various clinicopathologic parameters. Methods: p16 and EGFR expression was investigated by immunohistochemistry from paraffin-embedded tissue in 39 patients with adenocarcinoma of the uterine cervix. The immunohistochemical findings were correlated with different clinicopathologic parameters of the patients. Results: p16 was expressed in 56% of the patients. A trend towards increased lymph vascular space invasion was observed in p16 positive tumors (p=0.06). There was no statistically significant association between p16 expression and clinical stage, age, histology, tumor size, tumor grade, lymph node status and recurrence disease (p>0.05). p16 expression did influence neither disease-free nor overall survival (p>0.05). EGFR was expressed in 44% of the patients. There was no statistically significant correlation between EGFR expression and clinical stage, age, histology, tumor size, tumor grade, lymph vascular space invasion, lymph node status and recurrence disease (p>0.05). EGFR expression did influence neither disease-free nor overall survival (p>0.05). Conclusion: p16 and EGFR are frequently expressed in adenocarcinoma of the uterine cervix. Our study observed a trend towards increased lymph vascular space invasion in p16 positive tumors. Otherwise, the expression of the investigated parameters did not correlate with any clinicopathologic parameters and had no influence on overall and disease-free survival. So far, the investigation of p16 and EGFR is of limited use to assess patients' prognosis and guide clinical management. Springer-Verlag, 2010 p16 nationallicence Epidermal growth factor receptor nationallicence Adenocarcinoma nationallicence Uterine cervix nationallicence Bodner Klaus Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut Laubichler Peter Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut Kimberger Oliver Department of Anesthesiology, University of Vienna Medical School, Vienna, Austria aut Czerwenka Klaus Department of Gynecopathology, University of Vienna Medical School, Vienna, Austria aut Zeillinger Robert Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut Bodner-Adler Barbara Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 611-616 0932-0067 283:3<611 2011 283 404 https://doi.org/10.1007/s00404-010-1464-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1464-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bodner Klaus Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut NATIONALLICENCE 700 1- Laubichler Peter Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut NATIONALLICENCE 700 1- Kimberger Oliver Department of Anesthesiology, University of Vienna Medical School, Vienna, Austria aut NATIONALLICENCE 700 1- Czerwenka Klaus Department of Gynecopathology, University of Vienna Medical School, Vienna, Austria aut NATIONALLICENCE 700 1- Zeillinger Robert Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut NATIONALLICENCE 700 1- Bodner-Adler Barbara Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 611-616 0932-0067 283:3<611 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer