caa a22 4500 445307064 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1414-4 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1414-4 Efficacy and tolerability of a local acting antiseptic agent in the treatment of vaginal dysbiosis during pregnancy [Elektronische Daten] [Volker Briese, Gerd Neumann, Juliane Waldschläger, Theodor May, Jörg Siebert, Bernd Gerber] Objective: In the present study, the efficacy and tolerability of the local acting antiseptic octenidine hydrochloride/phenoxyethanol (OHP) for the treatment of vaginal dysbiosis (VD) and/or bacterial vaginosis (BV) in pregnancy and its potential influence on preterm births and low-weight newborns were examined. Methods: One-hundred nine pregnant women with increased pH values (>4.5) and BV characteristic symptoms were treated with OHP for 7days and a second time in case of a recurrent pH increase. pH values were continuously controlled by women's self-measurements. Results: pH decreased to ≤4.5 in 67.9% of patients. Seven of 12 women (58.3%) treated again with OHP due to a recurrent pH increase finally reached the pH target (pH≤4.5). No preterm birth occurred in the OHP group; no newborn had a birth weight <2,000g. Rates of preterm births and low-weight newborns were comparable between OHP group and pregnant women without VD/BV. Conclusions: OHP is effective and well tolerated in the treatment of VD/BV also in pregnancy without side effects and the occurrence of resistances. It could be an additional therapeutic option in the prevention of the multifactorial disease pattern ‘preterm birth' with all their consequences. Springer-Verlag, 2010 Vaginal infection nationallicence pH measurement nationallicence Preterm birth nationallicence Prevention nationallicence Octenidine hydrochloride nationallicence Briese Volker Gynaecological University Hospital and Polyclinic, Clinical Centre Südstadt Rostock, Südring 81, 18059, Rostock, Germany aut Neumann Gerd Endokrinologikum Hamburg, Centre for Hormonal and Metabolic Diseases, Gynaecologic Endocrinology and Prenatal Medicine, Hamburg, Germany aut Waldschläger Juliane Gynaecological University Hospital and Polyclinic, Clinical Centre Südstadt Rostock, Südring 81, 18059, Rostock, Germany aut May Theodor GBP, Society for Biometry and Psychometrics GbR, Bielefeld, Germany aut Siebert Jörg Schülke and Mayr GmbH, Norderstedt, Germany aut Gerber Bernd Gynaecological University Hospital and Polyclinic, Clinical Centre Südstadt Rostock, Südring 81, 18059, Rostock, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 585-590 0932-0067 283:3<585 2011 283 404 https://doi.org/10.1007/s00404-010-1414-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1414-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Briese Volker Gynaecological University Hospital and Polyclinic, Clinical Centre Südstadt Rostock, Südring 81, 18059, Rostock, Germany aut NATIONALLICENCE 700 1- Neumann Gerd Endokrinologikum Hamburg, Centre for Hormonal and Metabolic Diseases, Gynaecologic Endocrinology and Prenatal Medicine, Hamburg, Germany aut NATIONALLICENCE 700 1- Waldschläger Juliane Gynaecological University Hospital and Polyclinic, Clinical Centre Südstadt Rostock, Südring 81, 18059, Rostock, Germany aut NATIONALLICENCE 700 1- May Theodor GBP, Society for Biometry and Psychometrics GbR, Bielefeld, Germany aut NATIONALLICENCE 700 1- Siebert Jörg Schülke and Mayr GmbH, Norderstedt, Germany aut NATIONALLICENCE 700 1- Gerber Bernd Gynaecological University Hospital and Polyclinic, Clinical Centre Südstadt Rostock, Südring 81, 18059, Rostock, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 585-590 0932-0067 283:3<585 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer