caa a22 4500 445307080 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1382-8 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1382-8 The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial [Elektronische Daten] [Murat Ekin, Levent Yaşar, Kadir Savan, Muzaffer Temur, Mehmet Uhri, Işıl Gencer, Esra Kıvanç] Objective: To compare the effectiveness of the vaginal tablets of hyaluronic acid and estrodiol for the treatment of atrophic vaginitis. Materials and methods: Forty-two postmenopausal women with symptoms of atrophic vaginitis were randomized to take vaginal tablets of 25μg estradiol (n=21) (group I) or 5mg hyaluronic acid sodium salt (n=21) (group II) for 8weeks. The symptoms of atrophic vaginitis were evaluated by a self-assessed 4-point scale of composite score and the degree of epithelial atrophy was determined as, none, mild, moderate and severe. Vaginal pH and maturation index were measured and compared in both the groups. Results: The symptoms were relieved significantly in both the groups (P<0.001). The relief of symptoms was significantly superior in group I compared with group II (P<0.05). A significant decrease in epithelial atrophy and vaginal pH were detected in both the groups (P<0.01) after treatment. The vaginal maturation values were also significantly improved at both study groups (P<0.001). The mean maturation value was significantly higher in group I when compared with group II (P<0.001). Conclusion: Both treatments provided relief of vaginal symptoms, improved epithelial atrophy, decreased vaginal pH, and increased maturation of the vaginal epithelium. Those improvements were greater in group I. Hyaluronic acid vaginal tablets can be used in patients with atrophic vaginitis who do not want to or can not take local estrogen treatment. Springer-Verlag, 2010 Atrophic vaginitis nationallicence Hyaluronic acid nationallicence Vulvovaginal complaints nationallicence Ekin Murat Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut Yaşar Levent Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut Savan Kadir Medical Park Bahcelievler Hospital, Istanbul, Turkey aut Temur Muzaffer Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut Uhri Mehmet Department of Pathology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut Gencer Işıl Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut Kıvanç Esra Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 539-543 0932-0067 283:3<539 2011 283 404 https://doi.org/10.1007/s00404-010-1382-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1382-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ekin Murat Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yaşar Levent Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Savan Kadir Medical Park Bahcelievler Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Temur Muzaffer Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Uhri Mehmet Department of Pathology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Gencer Işıl Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kıvanç Esra Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 539-543 0932-0067 283:3<539 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer