caa a22 4500 445307102 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-009-1351-2 doi (NATIONALLICENCE)springer-10.1007/s00404-009-1351-2 Progesterone effects on preterm birth in high-risk pregnancies: a randomized placebo-controlled trial [Elektronische Daten] [Elcin Cetingoz, Cetin Cam, Mustafa Sakallı, Ates Karateke, Cem Celik, Ali Sancak] Purpose: The purpose of this study was to evaluate whether the prophylactic administration of vaginal progesterone would reduce the preterm birth rate in high-risk population including singleton and twin pregnancies. Methods: This was a randomized, double blind, placebo-controlled study that included 150 high-risk pregnancies. Risk groups included prior spontaneous preterm birth, twin pregnancy, and uterine malformation. Micronized progesterone or placebo (100mg) was administered daily by vaginal suppository between 24 and 34 weeks of gestation. We compared progesterone and placebo groups for incidence of preterm labor and preterm delivery. Data were compared by χ² analysis and Fisher exact test. Results: There was a statistically significant difference in the rate of preterm labor between placebo and progesterone groups (45.7 vs. 25%, respectively; p<0.05). More women delivered before 37 weeks in placebo group (57.2%) than in progesterone group (40%; p<0.05). Administering progesterone also reduced the preterm birth before 34 weeks of gestation. The difference between placebo and progesterone group was statistically significant (24.3 vs. 8.8%; p<0.05). However, there was no significant difference in neonatal death between placebo and progesterone groups. Conclusion: Prophylactic vaginal progesterone reduced the rate of preterm labor and preterm delivery in high-risk pregnancies. Springer-Verlag, 2010 Progesterone nationallicence Prevention nationallicence Preterm labor nationallicence Preterm delivery nationallicence Randomized trial nationallicence Cetingoz Elcin Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut Cam Cetin Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut Sakallı Mustafa Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut Karateke Ates Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut Celik Cem Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut Sancak Ali Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 423-429 0932-0067 283:3<423 2011 283 404 https://doi.org/10.1007/s00404-009-1351-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-009-1351-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cetingoz Elcin Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut NATIONALLICENCE 700 1- Cam Cetin Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut NATIONALLICENCE 700 1- Sakallı Mustafa Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut NATIONALLICENCE 700 1- Karateke Ates Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut NATIONALLICENCE 700 1- Celik Cem Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut NATIONALLICENCE 700 1- Sancak Ali Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 423-429 0932-0067 283:3<423 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer