caa a22 4500 445307153 CHVBK 20180317142616.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1371-y doi (NATIONALLICENCE)springer-10.1007/s00404-010-1371-y Urinary calcium and magnesium excretion relates to increase in blood pressure during pregnancy [Elektronische Daten] [Thorkild Nielsen, Ragnar Rylander] Objective: Pregnancy-induced hypertension and preeclampsia are serious clinical manifestations during late pregnancy and the cause for increased maternal and foetal morbidity and mortality. The pathogenesis is unknown but experience from treatment schemes suggests that minerals may be of importance. Mineral homeostasis is influenced by acid-base conditions. The aim of the study was to elucidate the relation between acid-base balance, urinary mineral excretion and blood pressure during pregnancy. Design: A prospective observational study of a general population. Materials and methods: The study was performed at the Midwife Health Center in Borås, Sweden, where practically all pregnant subjects in the catchment area are registered. First time pregnant subjects (n=123) were voluntarily recruited without exclusion criteria. A 24h urine sample was collected at pregnancy week 12 and analyzed for creatinine, calcium, magnesium, and urea as a proxy for acid conditions. Blood pressure was recorded every 2-3weeks until delivery. Results: There was a relation between the excretion of urea and calcium and magnesium at week 12. A blood pressure increase was found after pregnancy week 30 but only among subjects who had a high excretion of calcium and magnesium at week 12. Conclusions: If an increase in blood pressure during the later part of pregnancy a risk indicator for preeclampsia, the results suggest that an excessive secretion of calcium leading to a functional deficit might be a risk indicator for gestational hypertension and preeclampsia. Intervention experiments are required to assess this hypothesis. Springer-Verlag, 2010 Preeclampsia nationallicence Minerals nationallicence Acid-base nationallicence Calcium nationallicence Blood pressure nationallicence Nielsen Thorkild Department of Obstetrics and Gynecology, Hjorring Central Hospital, Hjorring, Denmark aut Rylander Ragnar BioFact Environmental Health Research Center, Bjorkasv 21, 44391, Lerum, Sweden aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 443-447 0932-0067 283:3<443 2011 283 404 https://doi.org/10.1007/s00404-010-1371-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1371-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nielsen Thorkild Department of Obstetrics and Gynecology, Hjorring Central Hospital, Hjorring, Denmark aut NATIONALLICENCE 700 1- Rylander Ragnar BioFact Environmental Health Research Center, Bjorkasv 21, 44391, Lerum, Sweden aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 443-447 0932-0067 283:3<443 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer