caa a22 4500 445307218 CHVBK 20180317142617.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1403-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1403-7 Menstrual phase-related differences in the pulsatility index on the central retinal artery suggest an oestrogen vasodilatation effect that antagonizes with progesterone [Elektronische Daten] [Luiz Viana, Marcos Faria, Heverton Pettersen, Marcos Sampaio, Selmo Geber] Purpose: The actual effect of steroid hormones on cerebral microcirculation is still controversial. Therefore, the aim of our study was to investigate vascular flow variations in the central retinal artery that may exist during the ovulatory menstrual cycle. Methods: A total of 34 healthy women were included in this observational, longitudinal, and prospective study. All participants were submitted to dopplerfluxometric evaluation of the eyes in order to study the pulsatility index (PI) of the central retinal arteries, during four phases of the menstrual cycle: early follicular, mid follicular, periovulatory, and mid luteal phases. Results: Subjects' ages ranged from 14 to 47years old (mean: 29.7±10.1) and PI did not differ among age groups. The PI of the central retinal artery was different among the four phases of the menstrual cycle. PI showed a significant decrease from early follicular phase (1.72) to mid follicular phase (1.57) (p=0.037), and was similar during periovulatory phase (1.56) and significantly increased in mid luteal phase (1.70). After that it returned to the values observed in the early follicular phase. Conclusion: Our results suggest the existence of an oestrogen vasodilatation effect on the central retinal artery that is menstrual phase-related and antagonized by progesterone. Springer-Verlag, 2010 Doppler nationallicence Central retinal artery nationallicence Menstrual cycle nationallicence Ovarian steroids nationallicence Viana Luiz Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil aut Faria Marcos ORIGEN, Center for Reproductive Medicine, Av. do Contorno, 7747, Lourdes, 30110-120, Belo Horizonte, Minas Gerais, Brazil aut Pettersen Heverton ORIGEN, Center for Reproductive Medicine, Av. do Contorno, 7747, Lourdes, 30110-120, Belo Horizonte, Minas Gerais, Brazil aut Sampaio Marcos ORIGEN, Center for Reproductive Medicine, Av. do Contorno, 7747, Lourdes, 30110-120, Belo Horizonte, Minas Gerais, Brazil aut Geber Selmo Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 569-573 0932-0067 283:3<569 2011 283 404 https://doi.org/10.1007/s00404-010-1403-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1403-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Viana Luiz Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil aut NATIONALLICENCE 700 1- Faria Marcos ORIGEN, Center for Reproductive Medicine, Av. do Contorno, 7747, Lourdes, 30110-120, Belo Horizonte, Minas Gerais, Brazil aut NATIONALLICENCE 700 1- Pettersen Heverton ORIGEN, Center for Reproductive Medicine, Av. do Contorno, 7747, Lourdes, 30110-120, Belo Horizonte, Minas Gerais, Brazil aut NATIONALLICENCE 700 1- Sampaio Marcos ORIGEN, Center for Reproductive Medicine, Av. do Contorno, 7747, Lourdes, 30110-120, Belo Horizonte, Minas Gerais, Brazil aut NATIONALLICENCE 700 1- Geber Selmo Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 569-573 0932-0067 283:3<569 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer