caa a22 4500 445307293 CHVBK 20180317142617.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1476-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1476-3 Risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers [Elektronische Daten] [Kerstin Rhiem, Dolores Foth, Barbara Wappenschmidt, Heidrun Gevensleben, Reinhard Büttner, Uwe Ulrich, Rita Schmutzler] Background: Risk-reducing salpingo-oophorectomy (RRSO) is often recommended to carriers of deleterious breast cancer gene 1/2 (BRCA1/2) mutations in order to reduce their breast cancer risk by 50% and their ovarian cancer risk by approximately 95%. To evaluate the acceptance, timing, histopathology findings and follow-up results we retrospectively analyzed a cohort of BRCA1/2 mutation carriers who underwent risk-reducing salpingo-oophorectomies. Methods: Between 1996 and 2009, 306 women who tested positive for a BRCA1 or BRCA2 mutation were counseled for preventive options. RRSO was recommended to all mutation carriers at age 40 or 5years prior to the earliest occurrence of ovarian cancer in the family. Data from 175 BRCA mutation carriers (92 BRCA1 and 83 BRCA2), who decided to undergo a RRSO, were analyzed. Data were collected from study entry until recent follow-up. Results: Fifty-seven percent of BRCA mutation carriers opted for RRSO. Mean age at time of surgery was 47years. Overall, one occult carcinoma of the fallopian tube was detected at the time of surgery in a 57-year-old woman and one primary peritoneal carcinoma occurred 26months after RRSO in a 59-year-old woman. Conclusion: Risk-reducing salpingo-oophorectomy is widely accepted. Recommendation of surgery at the age of 40 seems to be safe and the frequency of extraovarian primary peritoneal carcinoma after surgery is low. Springer-Verlag, 2010 BRCA nationallicence Risk-reducing salpingo-oophorectomy nationallicence Fallopian tube carcinoma nationallicence Primary peritoneal carcinoma nationallicence Follow-up nationallicence Rhiem Kerstin Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut Foth Dolores Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut Wappenschmidt Barbara Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut Gevensleben Heidrun Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany aut Büttner Reinhard Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany aut Ulrich Uwe Department of Obstetrics and Gynecology, Martin-Luther-Hospital, Caspar-Theyß-Str. 27-31, 14193, Berlin, Germany aut Schmutzler Rita Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 623-627 0932-0067 283:3<623 2011 283 404 https://doi.org/10.1007/s00404-010-1476-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1476-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rhiem Kerstin Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 700 1- Foth Dolores Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 700 1- Wappenschmidt Barbara Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 700 1- Gevensleben Heidrun Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany aut NATIONALLICENCE 700 1- Büttner Reinhard Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany aut NATIONALLICENCE 700 1- Ulrich Uwe Department of Obstetrics and Gynecology, Martin-Luther-Hospital, Caspar-Theyß-Str. 27-31, 14193, Berlin, Germany aut NATIONALLICENCE 700 1- Schmutzler Rita Center for Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/3(2011-03-01), 623-627 0932-0067 283:3<623 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer