caa a22 4500 445307374 CHVBK 20180317142617.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1717-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1717-5 Highly elevated serum CA-125 levels in patients with non-malignant gynecological diseases [Elektronische Daten] [Rong-Huan He, Wei-Miao Yao, Li-Yan Wu, Yu-Yan Mao] Purposes: To identify patients with highly elevated serum CA-125 levels and analyze their clinical characteristics. Methods: Patients with non-malignant gynecologic disease (NMGDs, n=41), in whom serum CA-125 levels were over 1,000IU/ml were retrospectively enrolled in the study. Seventy-one patients with epithelial ovarian cancer (EOC), in whom, serum CA-125 levels were over 1,000IU/ml were included as the comparison group. Clinical parameters were compared between the two groups. Results: In NMGDs group, 43.90% of the patients had endometriosis. The median of serum CA-125 level in NMGDs was much lower than that of EOC subjects (P<0.001). Compared to EOC group, the patients in NMGDs group were much younger (P<0.001) and had fewer histories of pelvic masses (P<0.001) but had more clinical complaints such as acute abdominal symptoms (P<0.001) and/or abnormal vaginal bleeding (P=0.022). Clinical progresses of these two groups were correlated with changes of serum CA-125 levels by follow-up for up to 386 days. Conclusions: High levels of serum CA-125 were found not only in the EOC, but also in some NMGDs, especially in the reproductive patients with complaints of acute abdomen symptoms or abnormal vaginal bleeding. Springer-Verlag, 2010 Cancer antigen 125 nationallicence Non-malignant gynecological diseases nationallicence Epithelial ovarian carcinomas nationallicence Tumor marker nationallicence He Rong-Huan Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, Zhejiang, People's Republic of China aut Yao Wei-Miao Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, Zhejiang, People's Republic of China aut Wu Li-Yan Department of Obstetrics and Gynecology, Yiwu Chouzhou Hospital, Yiwu, Zhejiang, People's Republic of China aut Mao Yu-Yan Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, Zhejiang, People's Republic of China aut Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 107-110 0932-0067 283<107 2011 283 404 https://doi.org/10.1007/s00404-010-1717-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1717-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- He Rong-Huan Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, Zhejiang, People's Republic of China aut NATIONALLICENCE 700 1- Yao Wei-Miao Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, Zhejiang, People's Republic of China aut NATIONALLICENCE 700 1- Wu Li-Yan Department of Obstetrics and Gynecology, Yiwu Chouzhou Hospital, Yiwu, Zhejiang, People's Republic of China aut NATIONALLICENCE 700 1- Mao Yu-Yan Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, Zhejiang, People's Republic of China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 107-110 0932-0067 283<107 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer