caa a22 4500 445307587 CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-011-1859-0 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1859-0 Successful pregnancy after cyclophosphamide therapy for lupus nephritis [Elektronische Daten] [Gabriela Lannes, Fernanda Elias, Bernardo Cunha, Nilson Jesus, Evandro Klumb, Elisa Albuquerque, Francinne Ribeiro] Background: Systemic lupus erythematosus (SLE) often requires administration of cyclophosphamide (CYC), especially for severe glomerulonephritis. As this disease usually affects young women in reproductive age, pregnancy, though not recommended may occur. The teratogenic effects of this drug make pregnancy prognosis and fetal survival indeterminate. Methods: We reviewed retrospectively the medical records of five patients with SLE who received inadvertently CYC during pregnancy and analyzed fetal outcome. Results: All patients were exposed at the first trimester. Two patients suffered miscarriages, two went to full term and one presented premature labor. Conclusion: In spite of potential successful pregnancies after CYC exposure, this drug has teratogenic effects and prescription must be avoided during the pregnancy period. At the same time, the occurrence of these reported unplanned pregnancies strengthen the need of improving patients' education on pregnancy risks during immunosuppressive treatment. Springer-Verlag, 2011 Systemic lupus erythematosus nationallicence Pregnancy nationallicence Cyclophosphamide nationallicence Teratogenesis nationallicence Glomerulonephritis nationallicence Miscarriage nationallicence Lannes Gabriela Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut Elias Fernanda Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut Cunha Bernardo Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut Jesus Nilson Division of Obstetrics, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil aut Klumb Evandro Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut Albuquerque Elisa Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut Ribeiro Francinne Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 61-65 0932-0067 283<61 2011 283 404 https://doi.org/10.1007/s00404-011-1859-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1859-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lannes Gabriela Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 700 1- Elias Fernanda Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 700 1- Cunha Bernardo Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 700 1- Jesus Nilson Division of Obstetrics, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 700 1- Klumb Evandro Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 700 1- Albuquerque Elisa Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 700 1- Ribeiro Francinne Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, 22220-040, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 61-65 0932-0067 283<61 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer