caa a22 4500 44530765X CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-010-1528-8 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1528-8 Association between consanguineous marriages and risk of pre-eclampsia [Elektronische Daten] [Zahra Anvar, Bahia Namavar-Jahromi, Mostafa Saadat] Purpose: The objective of this hospital-based case-control study was to assess the association between consanguinity and risk of pre-eclampsia in Shiraz (Fars Province, southern Iran) where the rate of consanguinity is relatively high. Methods: A total of 171 healthy pregnant women and 140 pre-eclamptic women were included. The healthy control group was frequency matched with the age of the pre-eclamptic women. Control women had no history of pregnancies with pre-eclampsia. Results: The prevalence of consanguinity was 42.8 and 30.9% in cases and controls, respectively. In univariate analysis, the mean inbreeding coefficient for cases (α=0.0218) was higher than that of controls (α=0.0174), denoting a significant difference (p=0.02). When family history was entered as a covariate in multivariate analysis, adjusted odds ratios (OR) revealed that the first cousin once removed (OR=4.11, 95% CI 1.32-12.7, p=0.014) increased the risk of pre-eclampsia, in comparison with unrelated marriages. Conclusions: Consanguinity in terms of first cousin once removed seems to be associated with pre-eclampsia after controlling for maternal age and family history of pre-eclampsia. Further investigations adjusting for other confounding factors are needed to confirm this information. Springer-Verlag, 2010 Consanguinity nationallicence Iran nationallicence Pre-eclampsia nationallicence Risk nationallicence Anvar Zahra Department of Biology, College of Sciences, Shiraz University, 71454, Shiraz, Iran aut Namavar-Jahromi Bahia Department of OB-GYN, Shiraz University of Medical Sciences, Shiraz, Iran aut Saadat Mostafa Department of Biology, College of Sciences, Shiraz University, 71454, Shiraz, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 5-7 0932-0067 283<5 2011 283 404 https://doi.org/10.1007/s00404-010-1528-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1528-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anvar Zahra Department of Biology, College of Sciences, Shiraz University, 71454, Shiraz, Iran aut NATIONALLICENCE 700 1- Namavar-Jahromi Bahia Department of OB-GYN, Shiraz University of Medical Sciences, Shiraz, Iran aut NATIONALLICENCE 700 1- Saadat Mostafa Department of Biology, College of Sciences, Shiraz University, 71454, Shiraz, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 5-7 0932-0067 283<5 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer