caa a22 4500 445307692 CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00404-011-1838-5 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1838-5 Peripartum anesthetic management of a patient with brittle cornea syndrome [Elektronische Daten] [A. Ioscovich, S. Grisaru-Granovsky, S. Halpern, Y. Shapiro] Brittle cornea syndrome (BCS) is a rare autosomol recessive disease that affects the connective tissue. The syndrome is caused by genetic changes in the 4.7-Mb interval between the D16S3423 and D16S3425 markers on the 16q24 chromosome and mutations in the Zinc-Finger 469 gene (ZNF469). BCS is characterized by thin and fragile cornea that tends to perforate spontaneously or as a result of minor trauma to the eye. In addition, the patient usually suffers from hearing loss, mental retardation, hyperextensibility of skin and joints, as well as varying degrees of scoliosis. This phenotypical expression presents an interesting challenge to anesthetic care. We briefly present the perioperative management of a patient with BCS who underwent three cesarean sections. Springer-Verlag, 2011 Obstetric nationallicence Anesthesia nationallicence Brittle cornea syndrome nationallicence Ioscovich A. Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Centre, Hebrew University, POB 3235, 91031, Jerusalem, Israel aut Grisaru-Granovsky S. Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel aut Halpern S. Department of Anesthesiology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Canada aut Shapiro Y. Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Centre, Hebrew University, POB 3235, 91031, Jerusalem, Israel aut Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 49-52 0932-0067 283<49 2011 283 404 https://doi.org/10.1007/s00404-011-1838-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1838-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ioscovich A. Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Centre, Hebrew University, POB 3235, 91031, Jerusalem, Israel aut NATIONALLICENCE 700 1- Grisaru-Granovsky S. Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel aut NATIONALLICENCE 700 1- Halpern S. Department of Anesthesiology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Shapiro Y. Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Centre, Hebrew University, POB 3235, 91031, Jerusalem, Israel aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283(2011-03-01), 49-52 0932-0067 283<49 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer