caa a22 4500 445307722 CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1776-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1776-7 The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat [Elektronische Daten] [Farideh Zangeneh, A. Mohammadi, Sh. Ejtemaeimehr, Mohammad Naghizadeh, Aminee Fatemeh] Background: This study was conducted to evaluate the effect of interaction of sympathetic and opioid systems in the processing of polycystic ovary syndrome modeling in rat. Methods: Ninety adult female rats (7-8weeks of age) were treated with EV for 60days for induction of follicular cysts (PCO modeling). Clonidine and yohimbine were used for sympathic agonist and antagonist and nalterxone was used for opioid system inhibition. Interactions of two systems were studied. Results: Our results indicate that both systems and interaction of two systems are effective in processing modeling of PCOS in rat. Interaction of two system drugs decreased estradiol (P<0.05). Qualitative analysis showed that the bulk of cysts and corpus lutea and dominant follicles were increased in PCO rats in comparison with control group. Conclusion: Therefore there could been an alternative in the treatment of the polycystic ovary syndrome in the rat by using adrenergic agonist and antagonists in combination with naltrexone. Springer-Verlag, 2010 Polycystic ovary syndrome (PCO) nationallicence Clonidine nationallicence Yohimbine nationallicence Nalterxone nationallicence Rat nationallicence Zangeneh Farideh Vali-e-Asr, Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran aut Mohammadi A. Medicine Faculty, Azad University, Tehran, Iran aut Ejtemaeimehr Sh Pharmacology Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran aut Naghizadeh Mohammad Central Biostatistics, Fasa University of Medical Sciences, Fasa, Iran aut Fatemeh Aminee Veterinary Faculty, Tehran University, Tehran, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 885-892 0932-0067 283:4<885 2011 283 404 https://doi.org/10.1007/s00404-010-1776-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1776-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zangeneh Farideh Vali-e-Asr, Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Mohammadi A. Medicine Faculty, Azad University, Tehran, Iran aut NATIONALLICENCE 700 1- Ejtemaeimehr Sh Pharmacology Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Naghizadeh Mohammad Central Biostatistics, Fasa University of Medical Sciences, Fasa, Iran aut NATIONALLICENCE 700 1- Fatemeh Aminee Veterinary Faculty, Tehran University, Tehran, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 885-892 0932-0067 283:4<885 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer