caa a22 4500 445307749 CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1718-4 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1718-4 Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis [Elektronische Daten] [Yaqin Huang, Wei Zheng, Lin Mu, Yuefang Ren, Xuejun Chen, Fang Liu] Objective: Our study is to investigate whether tyrosine kinase receptor B (TrkB) is expressed in eutopic endometrium of women with adenomyosis and its association with clinical characteristics. Methods: We collected endometrial tissues from 31 women with adenomyosis and 30 adenomyosis-free women undergoing surgery for benign indications. TrkB expression was assessed by immunohistochemistry and reverse-transcription polymerase chain reaction. Results: Immunoreactive staining for TrkB was present as brown flocculent precipitate in the endometrial cells. The average level of TrkB protein (quantitation of immunostaining intensity) in secretory endometrial samples of women with adenomyosis was significantly higher than that in controls (p<0.01). The average level of TrkB messenger RNA (mRNA) expression of women with adenomyosis was significantly higher than that of controls at secretory phase (p<0.01). In addition, the immunostaining quantitation of TrkB protein was positively correlated with the serum CA125 (r=0.308, p=0.016) and dysmenorrhea (r=0.393, p=0.002). Conclusions: Our study revealed elevation of TrkB protein and mRNA expression in the secretory endometrium of women with adenomyosis. Moreover, TrkB protein expression in human endometrium was positively correlated with the serum CA125 and dysmenorrhea. TrkB might contribute to the pathogenesis and progression of adenomyosis. The Author(s), 2010 Adenomyosis nationallicence Eutopic endometrium nationallicence Tyrosine kinase receptor B nationallicence Huang Yaqin Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut Zheng Wei Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut Mu Lin Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut Ren Yuefang Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut Chen Xuejun Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut Liu Fang Department of Pathology, Shaoxing People's Hospital, Shaoxing, Zhejiang, China aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 775-780 0932-0067 283:4<775 2011 283 404 https://doi.org/10.1007/s00404-010-1718-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1718-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Yaqin Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Zheng Wei Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Mu Lin Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Ren Yuefang Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Chen Xuejun Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, 310009, Hangzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Liu Fang Department of Pathology, Shaoxing People's Hospital, Shaoxing, Zhejiang, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 775-780 0932-0067 283:4<775 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer